prinnovo

What prinnovo does

Prinnovo is a Greensboro, North Carolina-based venture services firm founded in 2016 by Mark Rainosek and Jay Brennan that operates a proprietary 'Health Venture Office' (HVO) model for community health systems. The firm embeds dedicated teams of entrepreneurs and venture experts within mid-sized, independent community health systems to identify unmet innovation needs, source startup partners, negotiate equity-for-hidden-value arrangements (data, brand, validation, co-development, people, knowledge), and accelerate piloting and adoption. Prinnovo does not deploy significant capital; instead, it captures equity in healthcare startups in exchange for the operational contributions of its partner health systems, generating both near-term operational margin improvements and long-term equity upside.

The company's core product is the HVO itself — an embedded operating team — packaged alongside a collaborative network of HVOs that pools deal flow and negotiating leverage across systems. As of 2025, four HVOs are active: Cone Health Ventures (Greensboro, NC, 2019), Northeast Georgia Health Ventures (Gainesville, GA, 2022), Healthliant Ventures (Carrollton, GA, 2024), and Salinas Valley Health Ventures (Salinas, CA, 2025). Prinnovo manages an 18-company portfolio spanning AI radiology (RadAI, serving nearly half of U.S. health systems), radiation oncology workflow (Fuse Oncology, 250 contracted LINAC installations), patient engagement (Lirio), revenue cycle management, and other clinical and operational categories.

Prinnovo generates returns primarily through equity capture in portfolio companies (realized on acquisition or IPO) and through professional services associated with operational margin enhancement at partner health systems. Pricing is not publicly disclosed; the model explicitly substitutes health-system 'hidden value' for cash investment. The firm is privately held, reports 1-10 employees, and has no disclosed institutional funding rounds. Geographic footprint is concentrated in the Southeastern U.S. with a single California site established in 2025.

Name

prinnovo

Legal name

Prinnovo, LLC

Website

https://prinnovo.com

Company type

Private

Founded year

2016

Operating status

Operating

Headcount range

1–10 employees

Short description

Prinnovo operates a network of Health Venture Offices embedded within community health systems, sourcing and negotiating equity-for-hidden-value deals with healthcare startups. Founded 2016, with four HVOs active in NC, GA, and CA and an 18-company portfolio.

Ownership category

akta.pro rank

Product category

Healthcare Venture Services

NAICS

Funds, Trusts, and Other Financial Vehicles (525), Health and Welfare Funds (52512), Health and Welfare Funds (525120)

SIC

Services-Health Services (8000), Services-Misc Health & Allied Services, Nec (8090), Security Brokers, Dealers & Flotation Companies (6211)

akta.pro primary industry

Hospital Shared Services, GPOs & System Support Organizations (HLAFAAAO)

akta.pro secondary industry

Health Access & Social Care Innovations (Community Health, Telehealth for Underserved) (BPAGALAG)

Keywords

• Healthcare venture services
• Innovation consulting
• Health system partnerships
• Equity value capture
• Healthcare innovation advisory

Headquarters

HQ city

Greensboro

HQ country

United States

HQ region

North America

Offices4 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Marketing or Sales, Technology or R&D

Revenue model

1. Equity Value Capture: Prinnovo generates returns by capturing equity in healthcare startups in exchange for community health systems' hidden value contributions (data, brand, validation, co-development, people, knowledge). The equity holdings generate financial returns when portfolio companies are acquired or go public.
2. Operational Margin Enhancement: Near-term margin improvements within health system operations through validated innovation partnerships that drive millions of dollars of additional margin from improved clinical, financial, and operational outcomes.

Go-to-market motion2 records

Distribution channels1 record

Marketing channels3 records

Core offering

Prinnovo partners with community health systems through its proprietary Health Venture Office model, embedding dedicated teams of entrepreneurs and venture experts within partner health systems to identify and invest hidden value (data, brand, validation, co-development, people expertise, and knowledge) into innovative healthcare companies. In exchange, the health system captures equity in those startups without committing significant capital, generating both near-term operational margin improvements and long-term financial returns. Prinnovo operates a network of four Health Venture Offices across the United States that collaborate to attract promising healthcare companies and negotiate better deal terms.

Product overview

Prinnovo offers a unified Health Venture Office model/service rather than a traditional platform-plus-modules architecture. The Health Venture Office is an embedded team of entrepreneurs and venture experts that identifies, negotiates, and invests community health systems' hidden value into innovative healthcare companies. Prinnovo operates a Network of Health Venture Offices across multiple health systems (Cone Health, Northeast Georgia Health, Tanner Health, Salinas Valley Health) that collaborate to drive greater value together. The service enables health systems to capture equity in innovative healthcare companies without significant capital at risk, creates portfolio partnerships that drive near-term margin improvements and long-term financial returns, and facilitates innovation partnerships, joint ventures, and new venture opportunities.

Differentiator

Problem solved

Functional benefit

Brands

• Health Venture Office: An embedded, dedicated team of entrepreneurs and venture experts that identifies and invests hidden value of community health systems into innovative companies.
• THE PRINNOVO HEALTH VENTURE OFFICE

Products and services

• Health Venture Office

Quantifiable outcome

• Tens of millions of dollars in equity value generated for Cone Health over five years
• +7 more outcomes

Named customers4 records

Segments2 records

Ideal customer profiles1 record

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

14 partnerships are on record, tiered flagship, core and portfolio.

• Cone HealthflagshipStrategic or Co-development PartnerCone Health is the original partner where the Health Venture Office concept was first developed in 2016. Prinnovo established Cone Health Ventures in 2019 as the first Health Venture Office. Cone Health Ventures has generated tens of millions of dollars in equity value and created a large portfolio of holdings. Cone Health is a private, not-for-profit healthcare delivery system based in Greensboro, North Carolina with more than 13,000 employees, 1,800 physician partners, and 150+ locations including five hospitals.
• Northeast Georgia Health SystemcoreStrategic or Co-development PartnerPrinnovo established Northeast Georgia Health Ventures in 2022 for Northeast Georgia Health System, a not-for-profit community-based health system dedicated to improving health and quality of life in Northeast Georgia. NGHS operates multiple outpatient clinics and 5 acute care hospitals, with a large multi-specialty physician group of more than 1,400 physicians.
• Tanner HealthcoreStrategic or Co-development PartnerPrinnovo established Healthliant Ventures in 2024 for Tanner Health, a not-for-profit community-based health system established over 70 years ago. Tanner Health serves a nine-county area of more than 600,000 people in west Georgia and east Alabama, having grown from a single community hospital to a regional comprehensive healthcare provider.
• Salinas Valley HealthcoreStrategic or Co-development PartnerPrinnovo established Salinas Valley Health Ventures in 2025 for Salinas Valley Health Medical Center, a public district medical center in Salinas, California. The 263-bed acute care medical center employs more than 2,036 people with a medical staff of more than 300 board-certified physicians across a broad spectrum of specialties.
• Fuse OncologycoreStrategic or Co-development PartnerFuse Oncology was founded in August 2021 by BJ Sintay, PhD, David Wiant, PhD, and James Bauler, MA, from S!GNAL technology developed at Cone Health. Prinnovo supported the development, implementation, and piloting of Fuse Oncology's S!GNAL technology. The company has 250 contracted LINAC installations in progress across 13 U.S. states with contracts in 10 more. Fuse technology enables 90-95% efficiency gains in charge capture review and has achieved approximately 25x CAC/LTV ratio.
• RadAIcoreStrategic or Co-development PartnerRadAI was founded in 2018 by former Greensboro Radiology radiologist Jeff Chang. Prinnovo facilitated meetings between RadAI and Cone Health stakeholders and negotiated joint development and data use agreements. RadAI completed a $50 million Series B funding round and is recognized as the 19th fastest-growing company in North America by Deloitte. RadAI now serves almost half of all US health systems and 9 of the 10 largest radiology groups.
• LiriocoreStrategic or Co-development PartnerLirio is an innovative patient engagement platform selected by Cone Health Ventures to address care gaps and advance health equity. Cone Health and Lirio co-developed a targeted intervention program focused on engaging patients with hypertension and diabetes. The program resulted in 40% of engaged patients scheduling primary care appointments and 30% of diabetes intervention patients connecting with primary care providers.
• Lean TaaSportfolioTechnology or IntegrationLean TaaS is part of Prinnovo's portfolio of healthcare innovation partners, offering solutions for optimizing hospital operations with analytics and improving asset utilization.
• GlassbeamportfolioTechnology or IntegrationGlassbeam is part of Prinnovo's portfolio of healthcare innovation partners, providing analytics solutions for healthcare operations.
• ProcessBoltportfolioTechnology or IntegrationProcessBolt is part of Prinnovo's portfolio, offering automated vendor risk and attack surface monitoring solutions for healthcare organizations.
• CentivoportfolioTechnology or IntegrationCentivo is part of Prinnovo's portfolio, offering affordable primary care-based health plans to employers and employees.
• BabyscriptsportfolioTechnology or IntegrationBabyscripts is part of Prinnovo's portfolio, offering technology solutions for transforming maternity care.
• Dialyze DirectportfolioTechnology or IntegrationDialyze Direct is part of Prinnovo's portfolio, providing on-site and home dialysis services for better patient care.
• CortiportfolioTechnology or IntegrationCorti is part of Prinnovo's portfolio, offering AI-driven personalized patient communication solutions.

Scale indicators12 records

Recent moves11 records

Expansion highlights5 records

Regional players

• Heritage Provider Network: Heritage Provider Network is a California-based integrated provider organization that has historically invested in and incubated healthcare innovation ventures tied to its provider network. It overlaps thematically with Prinnovo's community-health-system innovation thesis but is itself a provider organization rather than a venture-services firm.

Direct peers

• Kaiser Permanente Ventures: Kaiser Permanente Ventures is the corporate venture arm of Kaiser Permanente, investing in healthcare technology and services startups in exchange for strategic alignment and equity. Comparable to Prinnovo in capturing equity for provider-side contributions, but operating exclusively for one integrated delivery network rather than across multiple community systems.
• Cedars-Sinai Accelerator: The Cedars-Sinai Accelerator runs cohorts of healthcare startups embedded within a large health system, providing validation, data, and clinical access in exchange for equity. It mirrors Prinnovo's thesis that health systems should capture equity from startups they help validate, though it is structured as time-limited cohorts rather than long-term embedded venture offices.
• Health Enterprise Partners: Health Enterprise Partners is a healthcare-focused growth equity and venture firm investing in companies serving providers and payers. While primarily an investor rather than an embedded operator, it shares Prinnovo's orientation toward community-based healthcare businesses and mid-sized provider organizations.
• Cleveland Clinic Innovations: Cleveland Clinic Innovations is one of the most established hospital venture arms, commercializing internal IP, running a portfolio of startups, and executing equity and licensing deals on behalf of the health system. It is comparable to Prinnovo's model of converting health-system hidden value (data, IP, brand) into equity, but it operates only for Cleveland Clinic rather than across multiple community systems.
• UPMC Enterprises: UPMC Enterprises is the venture, commercialization, and innovation arm of UPMC, investing in and co-developing healthcare startups with the health system's clinical and operational assets. It demonstrates the broader hospital-venture-arm archetype that Prinnovo's model is designed to bring to mid-sized community systems without in-house capabilities.
• Children's Hospital of Philadelphia Innovation (Office of Entrepreneurship & Innovation): CHOP's innovation office commercializes pediatric IP, runs accelerators, and takes equity in startups spun out of the hospital's research and clinical assets. It is structurally similar to Prinnovo's model of converting a non-profit provider's hidden assets into equity stakes, but operates within a single specialty health system.
• Mass General Brigham Innovation: Mass General Brigham Innovation licenses intellectual property, spins out companies, and invests in healthcare startups leveraging the system's research and clinical assets. It is a large-system analog to Prinnovo's community-system-focused Health Venture Office, both built around the idea that provider organizations should monetize their contribution to startup value creation.
• AVIA Health Innovation: AVIA (now part of Premier Inc.) partners with health systems to identify, evaluate, and deploy digital and innovation solutions, operating as an external innovation partner to provider organizations. Like Prinnovo, it acts as an embedded advisory layer that helps health systems capture value from innovation, though its model is consulting-based rather than equity-based.

Emerging players

• Redesign Health: Redesign Health launches and builds healthcare startups from scratch, often partnering with health systems and clinicians for validation and early adoption. It overlaps with Prinnovo's startup-creation and equity-capture playbook but tends to operate as a studio that retains majority ownership, rather than as an embedded venture partner for community health systems.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/prinnovo
• Xx.com/prinnovo

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Subsidiaries4 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about prinnovo