What Lipogen does

Lipogen is a privately held Israeli biotechnology company founded in 1991 that develops, manufactures, and sells phospholipid-based nutritional supplements, with headquarters in Haifa and US operations in Maine, South Portland, and West Chester, Ohio. The company's portfolio centers on three patented formulations built around phosphatidylserine (PS), phosphatidic acid (PA), and MCT oil: Lipogen PS Plus for memory and cognitive function, Lipogen PSPA for stress and cortisol management, and Lipogen PMS-FREE for premenstrual symptom relief. Lipogen manufactures its key ingredients in-house and is differentiated from herbal competitors by its clinical-evidence base — six completed double-blind trials and the only FDA Qualified Health Claim (2003) granted to a dietary supplement ingredient for dementia/cognitive dysfunction risk reduction, alongside FDA GRAS, EU Novel Food, ISO, GMP, HACCP and Kosher certifications.

Lipogen operates a largely direct-to-consumer commercial model: the company's primary revenue stream is its own e-commerce storefront (lipogenbio.com), with supplementary distribution via Amazon, a ShareASale-powered affiliate program paying 5% commission on a ~$100 average order, and a B2B ingredient-licensing agreement signed with Lonza in 2010. Product retail prices range $28.99–$104.97 per bottle, with free shipping and a 30- or 90-day money-back guarantee. Customer acquisition relies on content marketing, SEO, organic social (Facebook, Instagram), email, paid Meta/Google retargeting, customer testimonials, and an IAPMD partnership for PMS-targeted marketing. The company serves individual consumers across three primary use cases — adults seeking memory/cognitive enhancement, adults under chronic stress, and women with PMS — with a claimed cumulative base of more than one million customers worldwide and 100+ scientific articles referencing Lipogen research.

Lipogen is co-led by co-founders David Rutenberg (Co-CEO, VP R&D) and Ilan Perry (Co-CEO, COO, VP Product Development), supported by an advisory board that includes Weizmann Institute scientists Prof. Meir Shinitzky and Dr. Avner Sheinfeld, contract-research principal investigator Dr. Juliane Hellhammer (CEO of daacro), food engineer Hagit Lichtig Koren, IP strategist Dr. David Mualem, and geriatric medicine advisor Prof. Jacob Gindin. The organization has a small 1–10 employee footprint, no disclosed institutional funding, and a documented passing of co-founder/VP of Finance Doron Amir. Strategic positioning is anchored by 10 issued patents and a long regulatory track record rather than venture-scale growth signals.

Name

Lipogen

Legal name

Lipogen U.S. Inc.

Website

https://lipogenbio.com

Company type

Private

Founded year

1991

Operating status

Operating

Headcount range

1–10 employees

Short description

Lipogen is an Israeli biotechnology company (founded 1991) that develops and sells patented phospholipid-based dietary supplements — phosphatidylserine formulas for memory, cortisol/stress, and PMS relief — directly to consumers via e-commerce, with supplementary ingredient licensing to Lonza.

Ownership category

akta.pro rank

Product category

Cognitive Health Nutritional Supplements

NAICS

Fats and Oils Refining and Blending (311225), Starch and Vegetable Fats and Oils Manufacturing (31122), Food (Health) Supplement Retailers (456191)

SIC

Fats & Oils (2070), Medicinal Chemicals & Botanical Products (2833)

akta.pro primary industry

Omega-3 & Specialty Lipids (Fish/Algal Oils, EPA/DHA, MCTs, CLA, Phospholipids) (AFAJAKAC)

akta.pro secondary industries

Healthy Aging & Cognitive Support Supplements (CRADAGAM), Lipid-Based Emulsions & Encapsulated Oils (Spray-Dried Oils, Microencapsulation) (AFAJALAM)

Keywords

• Phospholipid supplements
• Brain health supplements
• Nootropic formulations
• Cognitive health products
• Stress management supplements

Headquarters

HQ city

Haifa

HQ country

Israel

HQ region

Middle East

Offices3 records

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Technology or R&D, Personnel, Marketing or Sales, Operations

Revenue model

1. Direct-to-Consumer E-commerce Sales: Lipogen sells its nutritional supplement products directly to consumers through its e-commerce storefront at lipogenbio.com. Customers purchase individual bottles of supplements at listed retail prices. Orders are processed within 24-48 hours and shipped within 3 business days.
2. Marketplace Sales (Amazon): Products are also available for purchase on Amazon, reaching customers through the Amazon marketplace channel. This complements the direct e-commerce channel.
3. Affiliate/Referral Revenue Share: Lipogen operates an affiliate program offering 5% commission on all qualifying sales with a 30-day cookie life. Affiliates (publishers, health and wellness bloggers, forums, review sites, social media influencers) promote Lipogen products and earn commission on resulting sales. Average order value is approximately $100, with product prices ranging between $28.99-$104.97.
4. Ingredient Licensing: Lipogen raw ingredients, used as ingredients in a variety of products, have been shown safe and effective in extensive clinical research. The company licenses its patented formulations and raw ingredient technology to other manufacturers. Lonza collaboration agreement was signed in 2010 for this purpose.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels9 records

Core offering

Lipogen develops, manufactures, and sells proprietary phospholipid-based nutritional supplements built around phosphatidylserine (PS), phosphatidic acid (PA), and MCT oil. The product portfolio targets three areas: brain health and cognitive enhancement (PS Plus), stress and cortisol management (PSPA), and premenstrual syndrome relief (PMS-FREE). Products are sold direct-to-consumer via the company's e-commerce site and Amazon, with patented formulations backed by clinical trials and FDA regulatory designations.

Product overview

Lipogen offers a portfolio of three clinically proven nootropic supplement products for brain health and wellness: Lipogen PS Plus™ (memory and focus), Lipogen PSPA™ (stress management and cortisol regulation), and Lipogen PMS-FREE™ (PMS relief in softgel and tablet formulations). All products are based on patented phospholipid formulas containing phosphatidylserine, phosphatidic acid, and MCT oil, designed to fortify brain cell membranes and support cognitive function. The company positions itself as the 'gold standard of nootropics' with products backed by published clinical studies and FDA Qualified Health Claims.

Differentiator

Problem solved

Functional benefit

Brands

• Lipogen PS Plus™: Brain health dietary supplement for improving memory and focus
• Lipogen PSPA™
• Lipogen PMS-FREE™

Products and services

• Lipogen PS Plus™

Quantifiable outcome

• In a double-blind, placebo-controlled study, elderly people with memory problems showed improved memory and mood (Wechsler Memory Scale) after taking Lipogen PS Plus.
• +5 more outcomes

Named customers9 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Four partnerships are on record, tiered core and minor.

• LonzacoreStrategic or Co-development Partner · 1 January 2010In 2010, Lipogen signed a collaboration agreement with Lonza, the large Swiss pharmaceutical company. The partnership involves collaboration on product development and ingredient licensing. A 2014 clinical study on Lipogen PSPA was published through the Lonza collaboration, and the study is referenced as 'Lonza-1' in research publications.
• International Association for Premenstrual Disorders (IAPMD)minorGTM or Marketing PartnerLipogen is a proud supporter of the International Association for Premenstrual Disorders (iapmd.org). This partnership provides credibility within the women's health community and supports Lipogen's PMS-FREE product marketing.
• ShareASale (Affiliate Network)minorChannel Partner/ Reseller/ DistributorLipogen uses the ShareASale affiliate network platform (join link: shareasale.com/join/86637) to manage its affiliate program. Affiliates earn 5% commission on sales and are tracked via a 30-day cookie window.
• daacro GmbH & Co. KG (Contract Research Organization)coreStrategic or Co-development Partnerdaacro is a leading full-service contract research organization that conducts research for pharmaceutical and dietary supplement companies worldwide. Dr. Juliane Hellhammer, CEO of daacro, serves as Lipogen's Principal Investigator and directs clinical trials including studies on Lipogen PSPA's effects on stress reactivity. daacro's Saliva Lab and Study Site perform the research and clinical trials.

Scale indicators6 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Onnit: Onnit (Alpha BRAIN) is a direct-to-consumer nootropics brand targeting brain performance, focus, and stress with similar product positioning and DTC go-to-market motion as Lipogen.
• Life Extension: Life Extension is a large, clinically-credentialed supplement brand selling phosphatidylserine and a wide range of cognitive, stress, and women's health formulations that directly compete with all three Lipogen product lines.
• Jarrow Formulas: Jarrow Formulas is a US-based supplement brand that sells phosphatidylserine products (e.g., Jarrow PS-100) directly competing with Lipogen PS Plus in the brain health category with similar ingredient positioning and price points.
• Doctor's Best: Doctor's Best sells a phosphatidylserine supplement and other brain health ingredients, competing in the same cognitive health category with science-emphasized branding similar to Lipogen's positioning.
• Source Naturals: Source Naturals is a science-focused supplement brand that sells phosphatidylserine and other nootropic/cognitive health products, with similar clinical-evidence-led marketing and a comparable premium price positioning.
• Integrative Therapeutics: Integrative Therapeutics is a practitioner-channel supplement brand with cognitive and stress products, providing a comparable clinician-recommended positioning to Lipogen's clinical-evidence-led brand.

Broad incumbents

• NOW Foods: NOW Foods is one of the largest US supplement manufacturers offering a phosphatidylserine product at lower price points, competing on the same ingredient with a much broader product portfolio and retail distribution.

Others

• Lonza: Lonza is the disclosed Lipogen licensing partner and a global CDMO/ingredient manufacturer operating in adjacent phospholipid and nutraceutical ingredient categories; useful as a B2B comparable for Lipogen's ingredient licensing business.

Emerging players

• Quicksilver Scientific: Quicksilver Scientific is a specialty supplement brand that uses phospholipid-based delivery (liposomal) technologies, overlapping with Lipogen's phospholipid expertise in novel lipid-based supplement formulations.
• Mind Lab Pro: Mind Lab Pro is a nootropics stack brand targeting cognitive performance with a similar premium DTC and affiliate-driven model as Lipogen, competing for the same self-optimizing consumer.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat3 records

Key risks6 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/LipogenPSplus
• Instagraminstagram.com/lipogen_pms_free
• LinkedInlinkedin.com/company/lipogen

Compliance6 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Lipogen