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Terra Biological

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uuid000r7ee

Namestring
Terra Biological
Legal namestring
Terra Biological LLC
Company typeenum
Private
Founded yearint
2006
Descriptiontext

Terra Biological LLC is a privately-held, family-owned biotechnology company founded in 2006 and headquartered in San Diego, California. The company develops and commercializes oxaloacetate-based nutraceuticals and medical food products targeting metabolic health, longevity, premenstrual emotional symptoms, and chronic fatigue syndrome. Its operating footprint spans globally via three dedicated e-commerce storefronts, with co-management by founder and Chief Science Officer Alan Cash and Sales and Marketing Manager Kathy Cash, supported by a small team of 1-10 employees.

The company's core technology is an oxaloacetate formulation developed from research into the molecular pathways of the calorie-restricted metabolic state. Working with researchers at UCSD, UCLA, and UC Riverside, the founder developed methods to stimulate the same molecular pathways associated with calorie restriction without reducing actual calorie intake. This platform underpins three branded products: benaGene (a longevity/metabolic nutraceutical), Jubilance (a nutraceutical for emotional PMS with demonstrated efficacy in randomized placebo-controlled trials on anxiety, gloominess, perceived stress and irritation), and Oxaloacetate CFS (a 90-capsule / 500mg medical food for the dietary management of ME/CFS). The company holds over 10 patents on the formula, has completed five clinical trials, and manufactures in GMP facilities with GLP toxicity testing.

Terra Biological generates revenue through direct-to-consumer e-commerce sales of its three branded products, sold globally through benaGene.com, Jubilance.com, and oxaloacetatecfs.com with no intermediary distribution partners. The customer base spans health-conscious consumers seeking longevity benefits without dietary restriction, women managing emotional PMS symptoms, and ME/CFS (and growing Long COVID) patients under physician supervision for dietary management of chronic fatigue. The company is privately funded by family ownership, with no institutional venture capital, public listing, parent company, or M&A activity disclosed.

Short descriptiontext

Terra Biological LLC is a privately-held, family-owned San Diego biotechnology company that develops and sells oxaloacetate-based nutraceuticals (benaGene, Jubilance) and a medical food (Oxaloacetate CFS) targeting metabolic health, PMS, and ME/CFS, distributed globally through direct-to-consumer e-commerce websites.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
1–10
akta.pro rankint
HeadquartersSan Diego, United States
HQ citystring
San Diego
HQ countrystring
United States
HQ regionstring
North America
Markets served

Serves global market

Offices2 records

Each record includes

City, Country, Type, Description, Source

Keyword5 values
nutraceutical products, medical foods, oxaloacetate supplements, calorie restriction research, direct-to-consumer supplements
Industry3 codes
1Healthy Aging & Cognitive Support Supplements
CodeCRADAGAMPrimaryYes
2Herbal & Botanical Supplements
CodeCRADAGADPrimaryNo
3Condition-Specific Bioactives (Glucosamine/Chondroitin, Plant Sterols, Melatonin, Lutein/Zeaxanthin)
CodeAFAJAKAKPrimaryNo
NAICS code2 codes
  • Medicinal and Botanical Manufacturing325411
  • Food (Health) Supplement Retailers456191
SIC code2 codes
  • Medicinal Chemicals & Botanical Products2833
  • Food And Kindred Products2000
Product category
Nutraceuticals and Medical Foods
Social media profiles1 record
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model1 record
1Direct-to-Consumer Product Sales
TypeOne Time License
Description

Terra Biological generates revenue through selling nutraceuticals (benaGene, Jubilance) and medical foods (Oxaloacetate CFS) directly to consumers via their e-commerce platforms. Products are sold globally.

terrabiological.com
Marketing channels1 record

Each record includes

Title, Type, Stage, Description, Source

Distribution channels1 record

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Supply Chain, Operations, Technology or R&D, Marketing or Sales, Personnel
GTM typeB2C
B2C
Offering typeHardware or Manufacturing
Hardware or Manufacturing
Brand1 of 3 records shown
1benaGene
Description

Oxaloacetate nutraceutical product developed from research into calorie restriction molecular pathways. The product holds over 10 patents and has undergone five clinical trials.

terrabiological.com
+2 more records
Core offering1 text field

Terra Biological LLC develops and sells oxaloacetate-based nutraceuticals and medical foods directly to consumers. Its portfolio includes benaGene (an anti-aging/longevity nutraceutical), Jubilance (an emotional PMS nutraceutical), and Oxaloacetate CFS (a medical food for the dietary management of Chronic Fatigue Syndrome / ME/CFS). Products are manufactured in GMP facilities, supported by GLP toxicity testing, and sold globally through dedicated e-commerce storefronts.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 value
  • In randomized placebo-controlled clinical trials, Jubilance significantly improved anxiety, gloominess, perceived stress and irritation associated with PMS
Product overview1 text field

Terra Biological is a biotechnology company that offers a portfolio of oxaloacetate-based nutraceuticals and medical foods. The core products include benaGene, a longevity-focused nutraceutical developed from calorie restriction research; Jubilance, a PMS-specific nutraceutical; and Oxaloacetate CFS, a medical food for Chronic Fatigue Syndrome. All products share the same active ingredient (oxaloacetate) but target different health conditions, with each formulation holding multiple patents and supported by clinical trials.

Product and service3 records
1benaGene (Oxaloacetate)
CategoryNutraceutical (anti-aging / longevity)
Description

A nutraceutical developed from research into calorie restriction molecular pathways, backed by more than 10 patents and five clinical trials. It stimulates the same molecular pathways as calorie restriction without reducing caloric intake, supporting cognitive health and anti-aging for health-conscious consumers.

2Jubilance (Oxaloacetate)
CategoryNutraceutical (women's health / emotional PMS)
Description

A nutraceutical formulated for Emotional Premenstrual Syndrome (PMS). In randomized placebo-controlled clinical trials, Jubilance significantly improved anxiety, gloominess, perceived stress, and irritation associated with PMS in women.

3Oxaloacetate CFS
CategoryMedical food (ME/CFS / Long COVID dietary management)
Description

A medical food consisting of a 90-capsule count of 500 mg Oxaloacetate capsules for the specific dietary management of Chronic Fatigue Syndrome (ME/CFS) patients and Long COVID symptom support. Does not require a prescription but requires physician supervision of use and dosage.

Scale indicator3 records

Each record includes

Type, Value, Description, Source

Partnership3 partners
Strategic tierCoreTypeStrategic or Co-development Partner
Description

Terra Biological collaborated with researchers at UCSD to develop their Oxaloacetate formula from research into the molecular pathways of the calorie restricted metabolic state.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

Terra Biological collaborated with researchers at UCLA on developing compounds that stimulate molecular pathways similar to calorie restriction.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

Terra Biological collaborated with researchers at UC Riverside in the research and development of their Oxaloacetate-based products.

Recent move4 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight3 records

Each record includes

Type, Description

Peers10 records
TypeDirect peer
Description

Elysium Health is a direct peer: a science-backed, premium-priced longevity supplement company (Basis/NAD+) selling primarily DTC with proprietary IP and clinical trial evidence. Both companies target the longevity and cellular health consumer segment with patented formulations and a credibility-driven marketing approach.

TypeDirect peer
Description

ChromaDex is a direct peer operating in the NAD+/anti-aging science space (Niagen/NR ingredient) with patented compounds, clinical research, and B2B/B2C commercialization. Both companies share the longevity/wellness thesis, IP-driven defensibility, and reliance on a single bioactives platform.

TypeDirect peer
Description

Bonafide Health is a direct peer in condition-specific women's health supplements (e.g., hot flashes, vaginal health) sold DTC with clinical evidence. Both companies target narrow women's health indications with single-active-ingredient products and physician-aligned credibility.

TypeBroad incumbent
Description

Life Extension is a broad incumbent in the longevity/life-span supplement category with a much broader catalog and direct-to-consumer/retail distribution. Both compete for the same science-minded longevity consumer, though Life Extension operates at significantly larger scale with hundreds of SKUs.

TypeBroad incumbent
Description

Nestlé Health Science is a broad incumbent spanning medical foods, clinical nutrition, and supplements (including Peptamen, Garden of Life). Both companies operate in the medical food category and target condition-specific dietary management, but Nestlé Health Science has vastly greater distribution and portfolio breadth.

TypeEmerging player
Description

Ritual is an emerging direct-to-consumer supplement brand emphasizing clinical-grade ingredients, third-party testing, and minimalist formulations. Comparable through shared DTC premium-positioning, science-forward branding, and focus on transparency, though Ritual focuses on daily multivitamins rather than condition-specific therapeutics.

TypeEmerging player
Description

Designs for Health is a professional-grade supplement company distributing through healthcare practitioners with condition-specific product lines. Both companies share the practitioner-aligned, condition-specific supplement positioning and clinical evidence emphasis.

TypeBroad incumbent
Description

Herbalife is a broad incumbent global nutrition company selling supplements and meal replacements through a multi-level marketing channel. While very different in scale and GTM, both are positioned in the consumer wellness supplement category with global distribution reach.

TypeBroad incumbent
Description

Pharmavite is a broad incumbent supplement manufacturer (Nature Made, MegaFood) supplying mass retail and drugstore channels. Both companies produce dietary supplements, though Pharmavite operates at vastly larger scale with mainstream retail distribution rather than DTC-only.

TypeEmerging player
Description

Kindra is an emerging direct-to-consumer brand targeting menopausal and perimenopausal women with condition-specific supplements. Both companies target narrow women's hormonal health indications with science-backed, single-active-ingredient formulations sold DTC.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat3 records

Each record includes

Type, Details

Key risks5 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Segment3 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile3 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature1 record

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles2 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Terra Biological

Nutraceuticals and Medical Foodsterrabiological.com

Terra Biological LLC is a privately-held, family-owned San Diego biotechnology company that develops and sells oxaloacetate-based nutraceuticals (benaGene, Jubilance) and a medical food (Oxaloacetate CFS) targeting metabolic health, PMS, and ME/CFS, distributed globally through direct-to-consumer e-commerce websites.

What Terra Biological does

Terra Biological LLC is a privately-held, family-owned biotechnology company founded in 2006 and headquartered in San Diego, California. The company develops and commercializes oxaloacetate-based nutraceuticals and medical food products targeting metabolic health, longevity, premenstrual emotional symptoms, and chronic fatigue syndrome. Its operating footprint spans globally via three dedicated e-commerce storefronts, with co-management by founder and Chief Science Officer Alan Cash and Sales and Marketing Manager Kathy Cash, supported by a small team of 1-10 employees.

The company's core technology is an oxaloacetate formulation developed from research into the molecular pathways of the calorie-restricted metabolic state. Working with researchers at UCSD, UCLA, and UC Riverside, the founder developed methods to stimulate the same molecular pathways associated with calorie restriction without reducing actual calorie intake. This platform underpins three branded products: benaGene (a longevity/metabolic nutraceutical), Jubilance (a nutraceutical for emotional PMS with demonstrated efficacy in randomized placebo-controlled trials on anxiety, gloominess, perceived stress and irritation), and Oxaloacetate CFS (a 90-capsule / 500mg medical food for the dietary management of ME/CFS). The company holds over 10 patents on the formula, has completed five clinical trials, and manufactures in GMP facilities with GLP toxicity testing.

Terra Biological generates revenue through direct-to-consumer e-commerce sales of its three branded products, sold globally through benaGene.com, Jubilance.com, and oxaloacetatecfs.com with no intermediary distribution partners. The customer base spans health-conscious consumers seeking longevity benefits without dietary restriction, women managing emotional PMS symptoms, and ME/CFS (and growing Long COVID) patients under physician supervision for dietary management of chronic fatigue. The company is privately funded by family ownership, with no institutional venture capital, public listing, parent company, or M&A activity disclosed.

Terra Biological firmographics

Firmographics
Name
Terra Biological
Legal name
Terra Biological LLC
Website
https://terrabiological.com
Company type
Private
Founded year
2006
Operating status
Operating
Headcount range
1–10 employees
Short description
Terra Biological LLC is a privately-held, family-owned San Diego biotechnology company that develops and sells oxaloacetate-based nutraceuticals (benaGene, Jubilance) and a medical food (Oxaloacetate CFS) targeting metabolic health, PMS, and ME/CFS, distributed globally through direct-to-consumer e-commerce websites.
Ownership category
akta.pro rank

Terra Biological industry classification

Industry
Product category
Nutraceuticals and Medical Foods
NAICS
Medicinal and Botanical Manufacturing (325411), Food (Health) Supplement Retailers (456191)
SIC
Medicinal Chemicals & Botanical Products (2833), Food And Kindred Products (2000)
akta.pro primary industry
Healthy Aging & Cognitive Support Supplements (CRADAGAM)
akta.pro secondary industries
Herbal & Botanical Supplements (CRADAGAD), Condition-Specific Bioactives (Glucosamine/Chondroitin, Plant Sterols, Melatonin, Lutein/Zeaxanthin) (AFAJAKAK)

Keywords

  • Nutraceutical products
  • Medical foods
  • Oxaloacetate supplements
  • Calorie restriction research
  • Direct-to-consumer supplements

Where Terra Biological is headquartered

Location

Headquarters

HQ city
San Diego
HQ country
United States
HQ region
North America

Offices2 records

Markets served

Terra Biological business model

Business model
GTM type
B2C
Offering type
Hardware or Manufacturing
Cost components
Supply Chain, Operations, Technology or R&D, Marketing or Sales, Personnel

Revenue model

  1. Direct-to-Consumer Product Sales: Terra Biological generates revenue through selling nutraceuticals (benaGene, Jubilance) and medical foods (Oxaloacetate CFS) directly to consumers via their e-commerce platforms. Products are sold globally.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels1 record

Terra Biological product offering

Product offering

Core offering

Terra Biological LLC develops and sells oxaloacetate-based nutraceuticals and medical foods directly to consumers. Its portfolio includes benaGene (an anti-aging/longevity nutraceutical), Jubilance (an emotional PMS nutraceutical), and Oxaloacetate CFS (a medical food for the dietary management of Chronic Fatigue Syndrome / ME/CFS). Products are manufactured in GMP facilities, supported by GLP toxicity testing, and sold globally through dedicated e-commerce storefronts.

Product overview

Terra Biological is a biotechnology company that offers a portfolio of oxaloacetate-based nutraceuticals and medical foods. The core products include benaGene, a longevity-focused nutraceutical developed from calorie restriction research; Jubilance, a PMS-specific nutraceutical; and Oxaloacetate CFS, a medical food for Chronic Fatigue Syndrome. All products share the same active ingredient (oxaloacetate) but target different health conditions, with each formulation holding multiple patents and supported by clinical trials.

Differentiator

Problem solved

Functional benefit

Brands

  • benaGene: Oxaloacetate nutraceutical product developed from research into calorie restriction molecular pathways. The product holds over 10 patents and has undergone five clinical trials.
  • Jubilance
  • Oxaloacetate CFS

Products and services

  • benaGene (Oxaloacetate) A nutraceutical developed from research into calorie restriction molecular pathways, backed by more than 10 patents and five clinical trials. It stimulates the same molecular pathways as calorie restriction without reducing caloric intake, supporting cognitive health and anti-aging for health-conscious consumers.
  • Jubilance (Oxaloacetate) A nutraceutical formulated for Emotional Premenstrual Syndrome (PMS). In randomized placebo-controlled clinical trials, Jubilance significantly improved anxiety, gloominess, perceived stress, and irritation associated with PMS in women.
  • Oxaloacetate CFS A medical food consisting of a 90-capsule count of 500 mg Oxaloacetate capsules for the specific dietary management of Chronic Fatigue Syndrome (ME/CFS) patients and Long COVID symptom support. Does not require a prescription but requires physician supervision of use and dosage.

Quantifiable outcome

  • In randomized placebo-controlled clinical trials, Jubilance significantly improved anxiety, gloominess, perceived stress and irritation associated with PMS

Companies that use Terra Biological

Customer profile

Segments3 records

Ideal customer profiles3 records

Terra Biological technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature1 record

Terra Biological partnerships and signals

Strategic signal

Partnerships

Three partnerships are on record, tiered core.

  • UCSD (University of California San Diego)coreStrategic or Co-development PartnerTerra Biological collaborated with researchers at UCSD to develop their Oxaloacetate formula from research into the molecular pathways of the calorie restricted metabolic state.
  • UCLA (University of California Los Angeles)coreStrategic or Co-development PartnerTerra Biological collaborated with researchers at UCLA on developing compounds that stimulate molecular pathways similar to calorie restriction.
  • UC Riverside (University of California Riverside)coreStrategic or Co-development PartnerTerra Biological collaborated with researchers at UC Riverside in the research and development of their Oxaloacetate-based products.

Scale indicators3 records

Recent moves4 records

Expansion highlights3 records

Terra Biological competitors and assessment

Company assessment

Direct peers

  • Elysium Health: Elysium Health is a direct peer: a science-backed, premium-priced longevity supplement company (Basis/NAD+) selling primarily DTC with proprietary IP and clinical trial evidence. Both companies target the longevity and cellular health consumer segment with patented formulations and a credibility-driven marketing approach.
  • ChromaDex: ChromaDex is a direct peer operating in the NAD+/anti-aging science space (Niagen/NR ingredient) with patented compounds, clinical research, and B2B/B2C commercialization. Both companies share the longevity/wellness thesis, IP-driven defensibility, and reliance on a single bioactives platform.
  • Bonafide Health: Bonafide Health is a direct peer in condition-specific women's health supplements (e.g., hot flashes, vaginal health) sold DTC with clinical evidence. Both companies target narrow women's health indications with single-active-ingredient products and physician-aligned credibility.

Broad incumbents

  • Life Extension: Life Extension is a broad incumbent in the longevity/life-span supplement category with a much broader catalog and direct-to-consumer/retail distribution. Both compete for the same science-minded longevity consumer, though Life Extension operates at significantly larger scale with hundreds of SKUs.
  • Nestlé Health Science: Nestlé Health Science is a broad incumbent spanning medical foods, clinical nutrition, and supplements (including Peptamen, Garden of Life). Both companies operate in the medical food category and target condition-specific dietary management, but Nestlé Health Science has vastly greater distribution and portfolio breadth.
  • Herbalife: Herbalife is a broad incumbent global nutrition company selling supplements and meal replacements through a multi-level marketing channel. While very different in scale and GTM, both are positioned in the consumer wellness supplement category with global distribution reach.
  • Pharmavite: Pharmavite is a broad incumbent supplement manufacturer (Nature Made, MegaFood) supplying mass retail and drugstore channels. Both companies produce dietary supplements, though Pharmavite operates at vastly larger scale with mainstream retail distribution rather than DTC-only.

Emerging players

  • Ritual: Ritual is an emerging direct-to-consumer supplement brand emphasizing clinical-grade ingredients, third-party testing, and minimalist formulations. Comparable through shared DTC premium-positioning, science-forward branding, and focus on transparency, though Ritual focuses on daily multivitamins rather than condition-specific therapeutics.
  • Designs for Health: Designs for Health is a professional-grade supplement company distributing through healthcare practitioners with condition-specific product lines. Both companies share the practitioner-aligned, condition-specific supplement positioning and clinical evidence emphasis.
  • Kindra: Kindra is an emerging direct-to-consumer brand targeting menopausal and perimenopausal women with condition-specific supplements. Both companies target narrow women's hormonal health indications with science-backed, single-active-ingredient formulations sold DTC.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat3 records

Key risks5 records

Key highlights7 records

Customer concentration

Terra Biological social profiles

Digital presence

Terra Biological financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Terra Biological leadership team

Management profile

Number of profiles

Profiles2 records

Terra Biological funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Terra Biological M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Terra Biological

What does Terra Biological do?

Terra Biological LLC develops and sells oxaloacetate-based nutraceuticals and medical foods directly to consumers. Its portfolio includes benaGene (an anti-aging/longevity nutraceutical), Jubilance (an emotional PMS nutraceutical), and Oxaloacetate CFS (a medical food for the dietary management of Chronic Fatigue Syndrome / ME/CFS). Products are manufactured in GMP facilities, supported by GLP toxicity testing, and sold globally through dedicated e-commerce storefronts.

Is Terra Biological a public or private company?

Terra Biological is a private company. It is classified as family owned and is currently operating.

When was Terra Biological founded?

Terra Biological was founded in 2006. It employs 1 to 10 people.

Where is Terra Biological based?

Terra Biological is headquartered in San Diego, United States, in the North America region.

How does Terra Biological make money?

One revenue line is on record: direct-to-Consumer Product Sales.

Who are Terra Biological's main competitors?

Direct peers on record are Elysium Health, ChromaDex and Bonafide Health. Broad incumbents are Life Extension, Nestlé Health Science, Herbalife and Pharmavite. Emerging players are Ritual, Designs for Health and Kindra.

Does Terra Biological have an API?

No public API is recorded for Terra Biological.

What industry is Terra Biological in?

Terra Biological's product category is Nutraceuticals and Medical Foods. Its primary akta.pro industry code is CRADAGAM, Healthy Aging & Cognitive Support Supplements, with a secondary code of CRADAGAD, Herbal & Botanical Supplements. Its NAICS code is 325411 and its SIC code is 2833.

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Live signals
PR.comTerra Biological LLC Expands Access to Oxaloacetate CFS Through HSA and FSA FundsTerra Biological LLC announced that eligible customers can now use HSA and FSA funds to purchase Oxaloacetate CFS, a medical food for ME/CFS and Long COVID. The partnership with Truemed aims to reduce out-of-pocket costs and increase access. The company also provides free wellness resources for the patient community.PR NewswireNew Study: Oxaloacetate Reduces Chronic Fatigue In Just Six Weeks, Promising Data for ME/CFS PatientsA clinical trial published in the Journal of Translational Medicine found that oral Anhydrous Enol-Oxaloacetate (AEO) significantly reduced fatigue in ME/CFS patients by 22.5% to 33.3% and in Long COVID patients by up to 46.8% over six weeks of treatment. The dose-dependent study used escalating doses ranging from 500mg to 3,000mg daily, with higher doses producing greater reductions in fatigue. Terra Biological LLC, which funded the study and distributes the medical food Oxaloacetate CFS, noted that higher therapeutic doses require supervision by a licensed healthcare provider.PR NewswireNew Study Finds Nutritional Supplement Jubilance Relieves PMS Mood SymptomsTerra Biological LLC announced that a peer-reviewed, randomized controlled clinical trial published in the Journal of Obstetrics and Gynecology Science found that daily supplementation with Jubilance, an over-the-counter nutritional supplement containing oxaloacetate (OAA), significantly reduced four core PMS-related mood symptoms within 30 days, including a 51 percent reduction in anxiety and 54 percent reduction in gloomy mood compared to placebo. In response to the trial results, the FDA has allowed Jubilance to include a structure/function claim regarding alleviation of mild to moderate PMS psychological and behavioral symptoms. The study, led by Dr. Lisa Tully, theorizes that oxaloacetate improves glucose metabolism in the brain and body, including the cerebellum which shows elevated glucose demands during PMS.PR NewswireFeminist Movement To End PMS Grows As Online CommunityA growing feminist movement is calling for increased scientific investment into premenstrual syndrome, particularly emotional PMS symptoms that affect an estimated 75 percent of menstruating women, with online communities on Facebook and Reddit serving as organizing hubs. Peer-reviewed clinical trials found that daily oxaloacetate (OAA) supplementation reduced PMS-related anxiety by 51 percent, gloomy mood by 54 percent, stress by 36 percent, and irritability by 18 percent after one month. Terra Biological LLC, a San Diego-based life sciences company, developed the Jubilance supplement, which the company and activists are promoting as a potential solution to a condition they argue has been historically neglected by the medical community.