OpiSafe

What OpiSafe does

OpiSafe is a Denver-based healthcare technology company, operated under the legal entity RxAssurance, that provides a SaaS platform addressing the full opioid lifecycle from acute pain prescribing through chronic pain management, overdose response, and addiction treatment. The platform is delivered as a core suite with modular products: OpiSafe for Pain, OpiSafe for MAT (medication-assisted treatment), OpiSafe for EHR, OpiSafe for Pharmacies, OpiRescue, OpiRescue HQ, and the OpiSafe Network, each targeting distinct buyer personas and clinical workflows. Underlying technology includes a service-oriented architecture with PHI-isolated APIs, 128-bit and SSL/TLS encryption, HL7/FHIR interoperability, proprietary multi-state PDMP API integration, and (via a 2026 strategic partnership with cliexa) AI-powered four-tier opioid use disorder risk prediction alongside two patent-pending systems for opioid tapering management and treatment referral with care coordination.

OpiSafe serves more than 700 pain prescribing practices, more than 300 addiction prescribing practices, high-volume and specialty pharmacies, public health departments, first responder agencies, and patients. The company runs a multi-channel go-to-market: enterprise direct sales to providers and pharmacies, listing in Epic App Orchard, AllScripts, and AthenaHealth marketplaces, channel partnerships with State Innovation Models, Departments of Public Health, Medicaid, and Attorney General offices for grant-funded or discounted access, and a freemium product-led growth motion via the free OpiRescue consumer app. Notable operational outcomes include a reduction in PDMP query time from an industry average of 3.5 minutes to 30 seconds and more than 40% monthly patient assessment completion rates, both materially above typical patient portal engagement.

Revenue is generated primarily through annual enterprise subscriptions for the OpiSafe modules (quote-based, not publicly disclosed) and OpiRescue HQ subscriptions for government agencies, supplemented by insurance-reimbursement-supporting reports and medical liability insurance discount programs. The consumer-facing OpiRescue app is offered free as a top-of-funnel adoption vehicle. The company is privately held, was founded in 2012 (rebranded to OpiSafe from RxAssurance), is headquartered in Denver, Colorado with a distributed remote workforce, and reports 11-50 employees. Disclosed funding to date totals $760,000 from The Colorado Health Foundation (2015), with a non-dilutive milestone from MedTech Innovator (2017), indicating a capital-efficient operating profile. The company holds HIPAA, HITECH, ISO 27001, SOC2 Type 2, and SOC3 certifications, which serve as procurement prerequisites in healthcare enterprise sales.

Name

OpiSafe

Legal name

RxAssurance

Website

https://opisafe.com

Company type

Private

Founded year

2012

Operating status

Operating

Headcount range

11–50 employees

Short description

OpiSafe is a Denver-based healthcare technology company providing a SaaS platform for opioid lifecycle management, serving 700+ pain prescribing practices, 300+ addiction practices, pharmacies, and government agencies with AI-powered risk prediction, PDMP integration, and overdose response tools.

Ownership category

akta.pro rank

Product category

Opioid Management Software

NAICS

Outpatient Mental Health and Substance Abuse Centers (621420), Individual and Family Services (6241)

SIC

Services-Prepackaged Software (7372), Services-Health Services (8000)

akta.pro primary industry

ePrescribing & Medication Workflow Platforms (EPCS, formulary, prior auth, med history) (HLALAIAD)

akta.pro secondary industries

Medication-Assisted Treatment (MAT) & Opioid Treatment Programs (OTPs) (HLAFACAG), Medication Adherence, Reminders & Patient Support (HLACAKAF)

Keywords

• Opioid management software
• Prescription drug monitoring
• Medication-assisted treatment
• Overdose response platform
• Clinical decision support

Headquarters

HQ city

Denver

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Marketing or Sales, Operations, Infrastructure

Revenue model

1. Enterprise Platform Subscriptions: Subscription-based access to OpiSafe for Pain, OpiSafe for MAT, OpiSafe for EHR, and OpiSafe for Pharmacies products targeting healthcare providers, pharmacies, and addiction treatment practices. Pricing is quote-based and not publicly disclosed.
2. OpiRescue HQ Enterprise Subscription: Subscription-based Overdose Response Management platform for government agencies, first responder departments, and public health departments to track overdose events and naloxone supplies. Available free to departments through local and federal grant programs.
3. OpiRescue Free Consumer App: Free smartphone app available for iOS and Android providing overdose recognition, naloxone administration guidance, and reporting. Serves as a freemium entry point for patient engagement and first responder adoption.
4. Insurance Reimbursement Supporting Reports: Reports documenting PDMP efficacy, toxicology administration, patient/provider agreements and assessments that have been shown to reduce claims inquiries and rejections, enabling practices to claim additional reimbursements.
5. Medical Liability Insurance Discounts: OpiSafe works with medical liability insurers to provide discounts and incentives for use of the platform in opioid prescribing practices, creating value for prescribers while establishing payer relationships.

Pricing tiers

Go-to-market motion4 records

Distribution channels5 records

Marketing channels6 records

Core offering

OpiSafe provides a software platform for healthcare providers, pharmacies, and public health agencies to manage the opioid lifecycle from acute and chronic pain prescribing through overdose response and addiction treatment. The platform combines automated PDMP/PMP querying, AI-powered risk stratification, EHR-integrated clinical decision support, patient engagement, and a network connecting pain and addiction prescribers for treatment referrals. The companion free OpiRescue app and OpiRescue HQ serve first responders and the public in recognizing and reversing overdoses.

Product overview

OpiSafe offers a platform-plus-modules architecture addressing the complete opioid lifecycle. The core OpiSafe Platform provides unified opioid intelligence with specialized modules: OpiSafe for Pain and OpiSafe for MAT serve different prescriber specialties; OpiSafe for EHR provides integration with Epic, AllScripts, and AthenaHealth; OpiSafe for Pharmacies enables automated dispensing workflow integration; OpiRescue delivers free mobile/web overdose reversal tools; OpiRescue HQ provides enterprise reporting for first responders; and the OpiSafe Network connects prescribers across the care continuum for treatment referrals.

Differentiator

Problem solved

Functional benefit

Brands

• OpiSafe: Comprehensive opioid management platform for healthcare providers, pharmacies, and patients addressing the opioid lifecycle from acute pain to addiction treatment.
• OpiRescue
• OpiRescue HQ
• OpiSafe Network

Products and services

• OpiSafe for Pain Clinical support module for providers prescribing opioids for pain, enabling misuse risk assessment, patient fill history monitoring, urinalysis tracking, aberrancy reporting, and proactive response to patient risk events.
• OpiSafe for MAT All-in-one clinical support for addiction prescribers using Medication-Assisted Treatment, combining comprehensive drug monitoring, patient engagement, risk stratification, and automated PDMP checks.
• OpiSafe for EHR EHR integration module that merges PDMP, toxicology lab, and patient-reported outcomes into a clinical decision support dashboard, integrating with Epic, AllScripts, and AthenaHealth within clinical workflows.
• OpiSafe for Pharmacies Pharmacy process automation and clinical tools enabling automated PDMP report checking, rules engine configuration for clinical standards, and direct integration into existing dispensing systems for high-volume and specialty pharmacies.
• OpiRescue Free smartphone and web app that helps first responders and the public recognize overdoses, reverse them with naloxone, and report the events; complements naloxone use for opioid overdose emergencies.
• OpiRescue HQ Reporting and analytics platform for first responder departments and government agencies to track overdose reversals, collect geodata, manage naloxone supplies, generate agency-level reports, and coordinate treatment referrals, including SAMHSA guidelines distribution and incident reporting.

Quantifiable outcome

• Reduces PDMP query time from 3.5 minutes to 30 seconds per patient
• +3 more outcomes

Named customers4 records

Segments6 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

AI capability4 records

Feature8 records

Partnerships

One partnership is on record.

• cliexacoreStrategic or Co-development Partner · 15 June 2026Strategic partnership announced June 15, 2026 to launch a comprehensive AI-powered platform for opioid stewardship and behavioral health management. The combined platform integrates cliexa's AI capabilities with OpiSafe's opioid management systems, including AI-powered opioid use disorder risk prediction with four-tier stratification, patented opioid tapering management, and patented treatment referral with care coordination. The partnership incorporates multiple issued and pending patents and represents a shift toward interoperable clinical intelligence ecosystems connecting risk identification through intervention and long-term treatment management. Target customers include health systems, payers, government agencies, and provider organizations.

Scale indicators6 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Bicycle Health: Bicycle Health provides online MAT and addiction medicine via telehealth across multiple states, competing with OpiSafe's MAT prescribers for the same addiction treatment practices and patient populations.
• DrFirst: DrFirst provides ePrescribing, medication history, EPCS, and PDMP-integrated workflows to hospitals and physician practices, directly competing with OpiSafe's provider-facing prescribing and medication workflow automation.
• Ophelia Health: Ophelia is a telemedicine-based MAT provider for opioid use disorder, serving patients directly and partnering with payers. It is a clinical-services competitor that also pressures OpiSafe's prescriber-facing MAT tooling.
• Pelago (formerly Quit Genius): Pelago delivers digital substance-use-disorder treatment (alcohol, opioid, tobacco) via telehealth and coaching for payers and employers, overlapping with OpiSafe for MAT and OpiSafe Network on addiction care coordination.
• Workit Health: Workit Health provides online Medication-Assisted Treatment (MAT) and therapy for opioid and alcohol use disorder, directly competing with OpiSafe for MAT and the treatment referral network on addiction prescriber workflows.
• Bamboo Health (formerly Appriss Health / PMP AWARxE): Bamboo Health operates PMP AWARxE, the dominant state PDMP platform, and care coordination tools. It is the most direct infrastructure competitor to OpiSafe's proprietary PDMP API and risk-stratification engine.

Emerging players

• Eleanor Health: Eleanor Health is an outpatient addiction treatment provider with a value-based, tech-enabled MAT and recovery model — a partial competitor to OpiSafe for MAT practices that may also buy OpiSafe's platform.
• Charlie Health: Charlie Health provides virtual intensive outpatient and mental-health treatment, partially overlapping with OpiSafe's behavioral-health and MAT positioning, especially given the cliexa partnership expansion.

Broad incumbents

• Surescripts: Surescripts is the largest U.S. ePrescribing network, providing medication history, benefit, and prior-authority infrastructure used by virtually all U.S. pharmacies and EHRs — a broad incumbent whose reach could subsume OpiSafe's narrower opioid workflow.
• Epic Systems (Opioid/Controlled Substance Workflows): Epic's EHR suite includes native controlled-substance prescribing, PDMP integration, and population-health opioid dashboards that compete with OpiSafe's EHR-embedded modules and could displace third-party apps.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/opisafe

Compliance8 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds2 records

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about OpiSafe