St Jude Children’s Research Hospital

What St Jude Children’s Research Hospital does

St. Jude Children's Research Hospital is a 501(c)(3) pediatric treatment and research institution founded in 1962 by entertainer Danny Thomas in Memphis, Tennessee, dedicated to advancing research and treatment for childhood cancer and other life-threatening diseases. It operates as an NCI-designated Comprehensive Cancer Center and the first and only WHO Collaborating Centre for Childhood Cancer, delivering inpatient and outpatient care, clinical trials, and survivorship support to pediatric patients and families at no charge for treatment, travel, housing, or food. The organization runs an integrated research platform spanning basic science, translational research, in-house GMP cell-therapy manufacturing, and clinical-trial delivery, including CRISPR/Cas9 pipelines for sickle cell disease, CAR T-cell programs (notably the 1922CAR bi-specific trial launched in February 2026), and the Combocat open-source ML plus acoustic-liquid-handling drug-combination discovery platform. Complementary capabilities include AI-augmented radiology (GPT-4-class report classification, MRI-based tumor-methylation prediction), the ASH HematOmics Program (ASHOP) data-sharing platform on 5,960 blood-cancer patients, and microbial cell-free DNA sequencing for early bloodstream-infection detection.

The hospital's research and care delivery is funded and operated alongside ALSAC (American Lebanese Syrian Associated Charities), the world's largest dedicated healthcare fundraising organization, founded in 1957 and staffed by 1,000+ national fundraising personnel supporting a workforce of 5,000+ at St. Jude itself. Revenue streams span mass-market individual giving (the Partner in Hope monthly sustaining program and one-time gifts), multi-decade corporate co-marketing partnerships (Domino's $162M+ cumulative toward a $300M-by-2034 goal; Costco, CVS, Williams-Sonoma), planned giving through the Heritage Society ($4.5B in bequests over the past decade, $800M+ in 2025), signature events (Dream Home Giveaway $650M+ cumulative, Walk/Run, Math-A-Thon), national fraternal service partnerships (Tri Delta $185M cumulative), government and federal grants (NCI $4.1M), cause-marketing per-transaction donations, workplace giving, and endowment investment income. The combined enterprise operates under a $12.9 billion six-year strategic plan (2022-2027) and is undergoing a planned CEO transition with James R. Downing, MD stepping down in late 2026. Distribution channels reach mass donors via broadcast TV PSAs (Thanks and Giving), direct mail, digital, SMS, events, school programs (Math-A-Thon via GoNoodle), and a national cause-marketing retail and restaurant network, while clinical reach extends through the Memphis campus, the affiliate clinic network (Huntsville, AL), St. Jude Global ministry-of-health partnerships, and NCI-funded clinical-trial networks.

Name

St Jude Children’s Research Hospital

Legal name

St. Jude Children's Research Hospital, Inc.

Website

https://stjude.org

Company type

Private

Founded year

1962

Operating status

Operating

Headcount range

5,001–10,000 employees

Short description

St. Jude Children's Research Hospital is a 501(c)(3) pediatric treatment and research institution in Memphis, TN, providing free cancer and catastrophic-disease care to children worldwide, funded by ALSAC, the world's largest dedicated healthcare fundraising organization, operating under a $12.9 billion six-year strategic plan.

Ownership category

akta.pro rank

Product category

Pediatric Cancer Treatment & Research

NAICS

Specialty (except Psychiatric and Substance Abuse) Hospitals (622310), General Medical and Surgical Hospitals (62211), Health Care and Social Assistance (62)

SIC

Services-Hospitals (8060), Services-General Medical & Surgical Hospitals, Nec (8062)

akta.pro primary industry

Children’s Hospitals (Acute Care) (HLAFAAAI)

akta.pro secondary industries

Children’s Hospitals & Pediatric Health Systems (HLAFAJAG), Disease-Specific Research & Support (e.g., Cancer, Diabetes, ALS) (BPAGACAA)

Keywords

• Pediatric cancer treatment
• Childhood cancer research
• Nonprofit hospital services
• Pediatric oncology care
• Cancer fundraising programs

Headquarters

HQ city

Memphis

HQ country

United States

HQ region

North America

Offices8 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales, Others

Revenue model

1. Individual Giving (cash + monthly recurring): Mass-market individual donations via direct mail, digital, phone, text. Includes the "Partner in Hope" monthly sustaining-donor program, the most-recognized retail fundraising product.
2. Corporate Partnerships & Co-Marketing: Multi-year, multi-million-dollar guaranteed annual commitments from national brands (Domino's, Costco, Kmart, CVS, Williams-Sonoma, etc.) operating co-branded campaigns and roundup donations.
3. Planned Giving / Bequests: St. Jude Heritage Society and Legacy of Hope planned-giving programs. $4.5B raised in bequests over the past decade; $800M+ in 2025 alone.
4. Signature Events & Galas: St. Jude Walk/Run, Dream Home Giveaway (operated with regional homebuilders), Math-A-Thon, Trike-A-Thon, Thanks and Giving Gala, and golf tournaments.
5. Foundations & Major Gifts: Multi-million-dollar cumulative giving from collegiate sororities, family foundations, and major donors. Tri Delta: $25M raised in 2026 toward $100M-by-2038 pledge.
6. Government & Federal Grants: National Cancer Institute $4.1M grant supporting Childhood Cancer Survivorship Study (announced by Congressman Steve Cohen).
7. Workplace Giving & CFC: Payroll deduction, employer matching, and Combined Federal Campaign participation.
8. Cause-Marketing / Per-Transaction Donations: Per-ticket / per-transmission donations through partners (e.g., Boom Ball: $20 per premium ticket, $1 per general ticket; Pro Motocross text-to-donate).
9. Investment Income from Endowment: Long-term endowment supporting research operations and patient-care subsidies.

Pricing tiers

Go-to-market motion6 records

Distribution channels9 records

Marketing channels9 records

Core offering

St. Jude Children's Research Hospital is a 501(c)(3) pediatric treatment and research institution that provides free inpatient and outpatient care for children with cancer, sickle cell disease, and other catastrophic pediatric illnesses, while running an integrated translational and clinical research program. Families never receive a bill for treatment, travel, housing, or food. The hospital also operates the largest dedicated healthcare fundraising organization (ALSAC), a global WHO Collaborating Centre for Childhood Cancer, GMP cell-therapy manufacturing, and the St. Jude Graduate School of Biomedical Sciences.

Differentiator

Problem solved

Functional benefit

Brands

• Together by St. Jude™: An online patient education and resource platform powered by St. Jude, providing information on childhood cancers, blood disorders, infectious diseases, treatments, and care.
• St. Jude Global
• St. Jude Gift Shop
• St. Jude LIFE Study
• St. Jude Cloud
• St. Jude Graduate School of Biomedical Sciences
• St. Jude Memphis Marathon Weekend
• St. Jude Dream Home Giveaway
• St. Jude Children's Research Hospital (and ALSAC)

Products and services

• Pediatric Cancer and Catastrophic-Disease Treatment Free inpatient and outpatient pediatric cancer, sickle cell, and catastrophic-disease treatment delivered at the Memphis campus and affiliate clinics. Families are never billed for treatment, travel, housing, or food. Treats infants through young adults (0–21 yrs) and accepts patients regardless of insurance or ability to pay.
• 1922CAR Bi-specific CAR T-Cell Clinical Trial Next-generation clinical trial program evaluating bi-specific CAR T-cell designs targeting CD19 and CD22 antigens in pediatric patients with relapsed/refractory blood cancers; supports the new Center of Excellence in Pediatric Immuno-Oncology. Builds on prior SJCAR19 outcomes.
• MIBEAP (MIBG Therapy) Clinical Trial Active clinical trial offering MIBG therapy for pediatric patients with high-risk neuroblastoma and other cancers that have not responded to standard treatments.
• CASPER CRISPR Gene Therapy for Sickle Cell Disease CRISPR-Cas9 gene therapy clinical trial and comprehensive sickle-cell center operated by St. Jude, with providers trained exclusively in sickle cell disease. Provides curative autologous blood-stem-cell gene-editing therapy for pediatric patients.
• Combocat Drug Combination Discovery Platform Open-source, freely available platform combining machine learning with acoustic liquid handling automation to accelerate high-throughput drug-combination discovery. Researchers tested 9,045 drug pairs against neuroblastoma cell lines.
• ASH HematOmics Program (ASHOP) Data Platform Open-source data-sharing platform integrating whole-genome sequencing, whole-transcriptome sequencing, and clinical data from 5,960 blood cancer patients with built-in analysis tools for the hematology research community.
• St. Jude Cloud Data-sharing platform within the St. Jude research ecosystem that makes pediatric cancer genomic and clinical data available to the global research community.
• Together by St. Jude Online patient-education and resource portal powered by St. Jude, providing information on childhood cancers, blood disorders, infectious diseases, treatments, and care for patients and families worldwide.
• PeCAN-PI (Pediatric Cancer Analytics Network) Open-access pediatric cancer analytics platform providing Python-based AI tools for patient-reported outcomes and clinical trial data, integrated with the federal Childhood Cancer Data Initiative (CCDI).
• St. Jude Global / Global Initiative for Childhood Cancer (GICC) Global health initiative (anchored in the WHO Collaborating Centre designation) delivering capacity-building, training, policy, and palliative-care support for pediatric cancer in low- and middle-income countries. Co-leads the Global Initiative for Childhood Cancer (GICC), which targets raising global 5-year pediatric cancer survival from 20% to 60% by 2030.
• Partner in Hope Monthly Giving Program Cornerstone monthly sustaining-donor program for mass-market individual donors, with recurring gifts starting at approximately $20 per month; the most-recognized retail fundraising product supporting St. Jude's no-bill patient model.
• St. Jude Dream Home Giveaway National home-giveaway fundraising program operated with regional homebuilders (Hanson Builders, The Providence Group, ICG Homes). Donors enter by contributing $100 per ticket, with cumulative program fundraising of more than $650 million.
• St. Jude Walk/Run National community walk/run fundraising event series with variable participant registration fees supporting St. Jude; held in cities across the U.S.
• St. Jude Math-A-Thon and Trike-A-Thon School Programs Curriculum-aligned K-8 school fundraising and education programs (movement-based math on GoNoodle STEM Lab and Trike-A-Thon for younger students). Free curriculum is paired with optional student-driven peer fundraising.
• St. Jude Heritage Society (Planned Giving) St. Jude planned-giving / legacy society program offering wills, bequests, charitable gift annuities, donor-advised funds, IRAs, and charitable trusts. Cumulative bequests of $4.5 billion over the past decade, including $800 million in 2025.
• St. Jude Thanks and Giving Campaign Annual national holiday fundraising and awareness campaign featuring broadcast TV PSAs with country-music and entertainment celebrities (Keith Urban, iHeartCountry, Bobby Bones) and co-branded corporate partner activations.
• St. Jude Gift Shop Online retail storefront whose purchases support St. Jude's mission. Operates as an own-brand e-commerce site at giftshop.stjude.org.
• St. Jude Graduate School of Biomedical Sciences Educational institution offering PhD and master's programs in biomedical sciences and clinical investigations; trains the next generation of pediatric cancer researchers.
• St. Jude LIFE Study (Childhood Cancer Survivor Cohort) Long-term longitudinal cohort study tracking the late outcomes of long-term childhood cancer survivors; receives federal NCI grant funding and serves as a research platform for survivorship science.
• St. Jude Memphis Marathon Weekend Annual fundraising marathon and race weekend in Memphis, Tennessee, presented by The Juice Plus+ Company since 2001, supporting St. Jude's mission.

Quantifiable outcome

• U.S. childhood cancer 5-year survival rate increased from 20% in 1962 to over 80% today
• +9 more outcomes

Named customers26 records

Segments6 records

Ideal customer profiles6 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration5 records

AI capability7 records

Feature10 records

Partnerships

32 partnerships are on record, tiered flagship, core and minor.

• Domino's PizzaflagshipStrategic or Co-development PartnerSt. Jude Thanks & Giving campaign; roundup donations; $162M+ raised since 2004; goal $300M by 2034. Includes Thanks & Giving, roundup, and St. Jude Walk events.
• Costco WholesalecoreStrategic or Co-development PartnerMulti-decade fundraising partnership; prominent in the Thanks & Giving campaign.
• Tri Delta SororityflagshipStrategic or Co-development PartnerNational service partnership since 1999; $185M cumulative; 2026 milestone $25M raised toward $100M pledge by 2038; 130+ chapters with ~400 members in attendance at the 2026 Memphis celebration.
• Mr Gatti's PizzaminorStrategic or Co-development PartnerLong-standing annual fundraiser; $10K+ raised in 2023 event; customer donations plus company matching.
• SEGA of America (Sonic the Hedgehog)coreStrategic or Co-development Partner35th anniversary livestream; Sonic Frontiers: Definitive Edition proceeds benefiting St. Jude.
• Pro Motocross / Monster Energy Supercross (Feld Entertainment)coreStrategic or Co-development PartnerAnnual text-to-donate and limited-edition t-shirt campaign; $800K single-season record in 2026; $3.5M+ cumulative.
• Hanson Builders (Maple Grove, MN)coreStrategic or Co-development PartnerSt. Jude Dream Home Giveaway builder; produced the largest-ever single donation ($1.23M).
• The Providence Group of Green Brick Partners (Atlanta)coreStrategic or Co-development PartnerAtlanta St. Jude Dream Home builder; $5.3M raised since 2023.
• Boom BallminorStrategic or Co-development Partner10-city inaugural 2026 summer tour; $20 per premium ticket, $1 per general ticket donated to St. Jude.
• Rocky Mountain ATV/MC + Feld EntertainmentminorStrategic or Co-development PartnerAnnual golf tournament fundraiser; $150K+ in third year.
• Guerra Wealth AdvisorsminorStrategic or Co-development PartnerChampion Sponsor, St. Jude Walk Miami, Sept 26, 2026.
• Oak Harvest Financial GroupminorStrategic or Co-development PartnerTitle Sponsor, 12th Annual St. Jude Houston Golf Classic.
• Assurance FinancialminorStrategic or Co-development PartnerExceeds $100K raised via Apps for Kids and Serve for St. Jude Pickleball Social.
• Melting Pot RestaurantsminorStrategic or Co-development Partner22nd annual St. Jude Thanks and Giving campaign; $1.5M+ target.
• Master SpasminorStrategic or Co-development Partner'Summer of St. Jude' campaign, July–Sept; $310K+ raised.
• Red Roof InnsminorStrategic or Co-development Partner'Room in Your Heart' holiday program; ~$250K raised since 2021.
• Varsity Spirit (CHEERSPORT)coreStrategic or Co-development Partner11th Annual Friday Night Live; $300K+ in 2026; $16M+ cumulative since 2011.
• Batteries PlusminorStrategic or Co-development Partner'Power with Purpose' program; second-year February 2026 campaign.
• iHeartCountry / Bobby BonescoreStrategic or Co-development PartnerAnnual iHeartCountry Festival and St. Jude radiothon; sponsored fundraising.
• Texas de BrazilminorStrategic or Co-development PartnerAnnual fundraising campaign; $125K raised Aug 1 – Oct 15, 2025.
• My Salon SuiteminorStrategic or Co-development PartnerAnnual fundraising; $129,215+ in Childhood Cancer Awareness Month; $946K+ since 2018.
• ICG Homes (Triangle / Raleigh)minorStrategic or Co-development Partner2026 St. Jude Dream Home builder (Triangle region).
• U.S. National Cancer Institute (NCI) / NIHflagshipStrategic or Co-development Partner$4.1M NCI grant to Congressman Steve Cohen supporting the St. Jude Childhood Cancer Survivorship Study.
• World Health Organization (WHO)flagshipStrategic or Co-development PartnerSt. Jude is the first and only WHO Collaborating Centre for Childhood Cancer; co-lead of the Global Initiative for Childhood Cancer (GICC).
• Congressman Steve Cohen (TN-9)coreGTM or Marketing PartnerFederal legislator and champion; announced $4.1M NCI grant for the St. Jude Childhood Cancer Survivorship Study.
• GoNoodle (STEM Lab channel)coreTechnology or IntegrationHosts St. Jude Math-A-Thon activities within STEM Lab; movement-based math for K-5 classrooms nationwide.
• Salesforce + Blackbaud (CRM vendors)coreTechnology or IntegrationCore donor-relationship management platforms for high-touch fundraising and AI-assisted donor engagement.
• Trust & Will (Featured Nonprofit Program)minorStrategic or Co-development PartnerSt. Jude named in the first featured cohort of Trust & Will's Featured Nonprofit Program alongside Doctors Without Borders and Susan G. Komen.
• BioCurie consortium (ARPA-H cell/gene therapy manufacturing)coreStrategic or Co-development PartnerMulti-institution ARPA-H project including St. Jude, Center for Breakthrough Medicines, Caring Cross, and University City Science Center; up to $9.3M ARPA-H funding for a cell/gene therapy manufacturing platform.
• Stanford, McMaster, and other research universitiescoreStrategic or Co-development PartnerMulti-institutional collaboration on CAR T-cell therapy for pediatric brain tumors (SITC Collaboration Award).
• Keith Urban and country music communitycoreGTM or Marketing PartnerLong-standing 'Angels Among Us' recognition; 20+ years of benefit concerts and campaign support.
• Window World Cares FoundationminorStrategic or Co-development PartnerRaised $19M+ for St. Jude since 2008 through community engagement and veteran-support programs.

Scale indicators25 records

Recent moves6 records

Expansion highlights7 records

Direct peers

• Children's Hospital of Philadelphia (CHOP): One of the largest U.S. pediatric academic medical centers with a leading pediatric oncology program and extensive research enterprise. Closely comparable to St. Jude as a top-tier children's hospital combining clinical care, translational research, and large-scale fundraising.
• Boston Children's Hospital: Harvard-affiliated pediatric hospital with a comprehensive cancer center (Dana-Farber/Boston Children's) and one of the largest pediatric research portfolios in the U.S. Directly comparable as a peer pediatric treatment and research institution.
• Texas Children's Hospital: Baylor College of Medicine-affiliated pediatric hospital and one of the largest in the U.S., with a major cancer center and significant fundraising operations. Comparable to St. Jude in scale, pediatric cancer focus, and research output.
• Cincinnati Children's Hospital Medical Center: Top-ranked U.S. pediatric hospital with major oncology and research programs, large endowment, and substantial federal funding. Directly comparable in clinical-research integration and pediatric specialty depth.
• Children's Healthcare of Atlanta: Large pediatric health system with the Aflac Cancer and Blood Disorders Center, one of the largest pediatric cancer programs in the U.S. Comparable in pediatric oncology volume and research scope.
• Susan G. Komen: Large U.S. health nonprofit focused on a specific disease (breast cancer), running the world's largest breast-cancer fundraising operation with comparable mass-market donor marketing and corporate partnerships. Highly comparable operating model even though disease focus differs.

Broad incumbents

• Memorial Sloan Kettering Cancer Center (Pediatric Program): NCI-designated Comprehensive Cancer Center with a dedicated pediatric oncology service. Broader than St. Jude (adult + pediatric) but directly comparable in research depth and NCI designation.
• Dana-Farber Cancer Institute: Harvard-affiliated NCI-designated Comprehensive Cancer Center with a joint pediatric program through Boston Children's. Comparable research enterprise and NCI designation, though broader in scope than St. Jude.
• Fred Hutchinson Cancer Center: NCI-designated Comprehensive Cancer Center with significant pediatric oncology and bone-marrow-transplant programs. Comparable in translational research and federal-grant scale, broader than St. Jude's pediatric-only focus.
• American Cancer Society: Largest U.S. voluntary health organization with broad cancer research funding, patient support, and national fundraising infrastructure. Comparable in nonprofit scale, federal-grant relationships, and nationwide cause-marketing footprint.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/stjude
• YouTubeyoutube.com/user/MyStJude
• Facebookfacebook.com/stjude
• LinkedInlinkedin.com/company/st-jude-childrens-research-hospital
• Instagraminstagram.com/stjude

Revenue estimate

Valuation estimate

Number of profiles

Profiles13 records

Subsidiaries1 record

Funding overview

Funding rounds12 records

Investors9 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about St Jude Children’s Research Hospital