Clinical Research IO
CRIO operates a cloud-based eClinical platform with eSource, EDC, eConsent, CTMS, and eRegulatory modules, selling to clinical research sites, sponsors, CROs, and academic centers across 30+ countries. Founded in 2015 in Boston, the company is private-equity-backed and serves 3,000+ research sites on 6,000+ protocols.
- Company typePrivate
- Founded2015
- HeadquartersBoston, United States
- Headcount101–250
- GTM typeB2B
- OfferingSoftware
What Clinical Research IO does
CRIO, Inc. (doing business as Clinical Research IO or CRIO) is a Boston-based health-technology company that operates a cloud-native eClinical platform anchored by an electronic source data capture (eSource) system for clinical trials. Founded in 2015 by Raymond Nomizu and Phuc Truong—both former site operators—the platform captures clinical-trial data directly at the point of patient interaction through configurable templates, protocol-driven edit checks, and integrated modules spanning electronic data capture (Reviewer EDC), eConsent, Site CTMS, eRegulatory, and reporting. A distinctive dual-database architecture separates PHI-enriched site instances from sponsor-side anonymized study databases, and a direct BigQuery replica exposes data to clients' business-intelligence tools with roughly 15-minute latency. The platform supports six languages across deployments in more than 30 countries.
CRIO serves four primary buyer segments: pharmaceutical and biotech sponsors, contract research organizations (CROs), independent and network clinical-research sites, and academic medical centers and decentralized-trial providers. Since 2025 the company has also sold Central eSource directly to sponsors and CROs, allowing enterprise buyers to deploy a central source template across participating sites while preserving local configuration. Pricing is quote-based, structured as annual subscriptions, with sponsors funding Central eSource deployments and sites gaining opt-in access without incremental charges.
The company sells primarily through direct enterprise field sales to sponsors, CROs, and site networks, supplemented by self-serve onboarding for individual sites via geographic portals and a 30+-partner channel ecosystem that includes Medidata (Dassault Systèmes) as a flagship technology partner, recruitment vendors, payment and patient-concierge providers, and implementation consultancies. The Riverside Company made a significant private-equity investment in May 2024 to accelerate international expansion, product development, and customer support. CRIO holds HIPAA, GDPR, 21 CFR Part 11, EU Annex 11, SOC 2 Type II, ISO 27001, GCP, HITECH, and CCPA certifications.
Clinical Research IO firmographics
Firmographics- Name
- Clinical Research IO
- Legal name
- CRIO, Inc.
- Website
- https://clinicalresearch.io
- Company type
- Private
- Founded year
- 2015
- Operating status
- Operating
- Headcount range
- 101–250 employees
- Short description
- CRIO operates a cloud-based eClinical platform with eSource, EDC, eConsent, CTMS, and eRegulatory modules, selling to clinical research sites, sponsors, CROs, and academic centers across 30+ countries. Founded in 2015 in Boston, the company is private-equity-backed and serves 3,000+ research sites on 6,000+ protocols.
- Ownership category
- akta.pro rank
Clinical Research IO industry classification
Industry- Product category
- Clinical Trial eSource Software
- NAICS
- Custom Computer Programming Services (541511)
- SIC
- Services-Prepackaged Software (7372)
- akta.pro primary industry
- Patient Recruitment, Site Feasibility & Trial Enablement CROs (HLAGAAAI)
Keywords
Where Clinical Research IO is headquartered
LocationHeadquarters
- HQ city
- Boston
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Clinical Research IO business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Technology or R&D, Personnel, Operations, Marketing or Sales, Infrastructure
Revenue model
- SaaS Subscription Platform: CRIO operates as a SaaS platform providing eSource, EDC, CTMS, eRegulatory, and eConsent solutions on a subscription basis. The platform is sold to clinical research sites, sponsors, and CROs. Sites that are existing CRIO clients are not charged for Central eSource studies if they opt-in — sponsors pay for Central eSource.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Enterprise/Sponsor Plans |
Go-to-market motion3 records
Distribution channels3 records
Marketing channels9 records
Clinical Research IO product offering
Product offeringCore offering
Clinical Research IO (CRIO) is a health technology company that builds and sells a cloud-based eSource (electronic source data capture) platform for clinical trials. The platform enables research sites to capture clinical trial data directly at the point of patient interaction, with integrated modules for EDC, eConsent, CTMS, eRegulatory, and reporting. CRIO sells subscriptions to sponsors, CROs, site networks, independent sites, academic medical centers, and decentralized clinical trial providers.
Product overview
CRIO offers a unified eClinical platform with eSource at its core, combining Central eSource® (for sponsors and CROs) and Site eSource (for sites) with integrated modules including Reviewer EDC, eConsent, Site CTMS, eRegulatory, and Reporting. The platform is built for sites and designed to streamline clinical trial operations by capturing quality data at the point of collection, driving protocol compliance, and reducing administrative burden across sponsors, CROs, and research sites.
Differentiator
Problem solved
Functional benefit
Products and services
- eSource Platform Foundational electronic source data capture platform enabling clinical trial sites to collect data directly at the point of patient interaction with protocol-driven edit checks and integrated workflows.
- Central eSource® Centralized eSource solution allowing sponsors and CROs to develop a central source template, publish it to sites for local configuration, and enable real-time data access and remote monitoring across all sites.
- Site eSource Site-based eSource platform for clinical trial sites, networks, and academic medical centers to capture source data in real time with configurable templates, automated protocol checks, and integrated workflows.
- Reviewer EDC Native electronic data capture (EDC) solution integrated with CRIO eSource, enabling real-time remote monitoring, data review, query management, PI signature collection, and automated data flow with built-in WHODrug and MedDRA coding dictionaries.
- eConsent Electronic informed consent module integrated with eSource workflow that automates ICF management, tracks consent versions, enables remote consenting with PIN verification, and eliminates missed re-consent deviations.
- Site CTMS Site clinical trial management system for patient recruitment, scheduling, financial management, and operational streamlining, integrated with CRIO eSource platform and including a Medical Records API for EHR-to-eSource data pipeline.
- eRegulatory Electronic regulatory binder solution that eliminates paper, enables electronic investigator site files (eISF), automates training document management, and provides digital delegation logs.
- Reporting Comprehensive reporting suite with standard reports, custom report creation tools, direct data access to BigQuery replica database with approximately 15 minutes latency, and integration with business intelligence tools like Looker.
- Publisher Centralized application for sponsors and CROs to create, version, and push study templates to sites globally, enabling rapid template distribution and study startup.
Quantifiable outcome
- 40% higher enrollment for CRIO-powered sites vs. non-CRIO sites
- +11 more outcomes
Companies that use Clinical Research IO
Customer profileNamed customers16 records
Segments6 records
Ideal customer profiles6 records
Clinical Research IO technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- Yes
- API docs
- API detail
Core technology
AI maturity
App detail
Integration34 records
AI capability8 records
Feature10 records
Clinical Research IO partnerships and signals
Strategic signalPartnerships
34 partnerships are on record, tiered flagship, core, minor and strategic.
- Medidata (Dassault Systèmes)flagshipStrategic partnership integrating CRIO's eSource platform with the Medidata Platform, connecting over 2,500 research sites across approximately 30 countries. The integration automates transfer of clinical data from research sites directly into electronic data capture systems, achieving near 100% data accuracy and 90% faster data entry.
- Grove (Grace AI Agent)coreAI-powered patient-matching platform that identifies, prescreens, schedules, and enrolls participants. Grace is multi-lingual and scales instantly for sites.
- Accelerate Recruitment ServicescoreClinical trial patient recruitment specialist offering strategic planning, recruitment and retention programs, and TruView platform for real-time engagement and reporting.
- StudyKIKcoreGlobal patient recruitment and retention platform offering digital marketing campaigns, dedicated study websites, global call center, telemedicine, SMS texting, and patient data management.
- TriallycoreAI-powered trial tech platform connecting to sites' clinical data and augmenting staff abilities to recruit, find studies, and prove feasibility.
- BEKhealthcoreAI-powered patient-matching platform extracting structured and unstructured data from EMRs that captures three times more trial criteria for feasibility and patient identification.
- PatientACEcoreSite-centric patient recruitment enabling easy setup of Facebook and Instagram ad campaigns with real-time lead delivery and automated text follow-up, seamlessly integrated with CRIO.
- Patient Recruiting Agency (TPRA)minorGlobal patient recruitment services including online and traditional media production, strategy development, and campaign placement with RADIUS365 referral delivery system integrated into CRIO.
- Precision RecruitmentminorAI-powered patient pre-screening and qualification call center with scalability of outsourced service.
- Delve HealthminorPatient concierge services increasing patient satisfaction, streamlining patient flow, and decreasing clinician burnout for improved retention.
- ClinrolminorAI-powered patient referral matching, pre-screening, and global patient recruitment services.
- CSSi (Rockstar Solution)minorTurnkey recruitment with real referrals and local support delivering fast starts, high ROI, and full-service retention.
- OMNI CRSminorPatient recruitment organization specializing in targeted lead generation, campaign management, and screener development.
- PowerminorPlatform helping people find and access leading medical researchers to accelerate medical innovation.
- Todata (SiteGrades)coreClinical research site operational data analytics transforming complex data into proactive insight and confident decision making.
- e4 HealthcoreHealth IT experts delivering structured CRIO implementation, legacy data mapping, and validation support for seamless site transitions.
- CoreforacoreeSource management service handling builds, payments, team training, and capacity support so sites can focus on patients.
- Dash SolutionscoreClinical trial payment solutions enabling meaningful payments to patients through cash cards with prepayments and 1099 year-end reporting.
- Clinical Research BillingminorRevenue cycle management ensuring sites get paid for all work performed.
- InatominorFree clinical trial marketplace allowing sites to showcase capabilities and get selected for global trials with top sponsors.
- Site SearchminorComprehensive data reports and datasets for performance assessment, expansion insights, and strategic partnerships.
- Clinical Science Research SolutionsminorCRIO-integrated site development, workforce training, and DEI education for launching clinical research sites in underserved areas.
- Elevate Clinical ResearchminorSite Management Organization providing EDC data entry, eRegulatory management, and patient recruitment services.
- Koncord Clinical Research Services (KCRS)minorExpert site management and tailored solutions ensuring efficient, high-quality clinical study execution.
- UniTriTeamminorExpert staff augmentation and CRIO tech solutions streamlining operations and boosting efficiency.
- Healthcare Business AssociatesminorStrategic support for healthcare practices and research sites with commitment to long-term success.
- Pluto HealthstrategicPartnership (2023) connecting care and research through innovative integration of healthcare data.
- mdgroupcoreDecentralized clinical solutions and vendor management provider enabling home health visits with CRIO for real-time source data access.
- Heart of AustraliacoreMobile clinical research site using CRIO for flexible trial delivery and document storage in remote areas.
- EMS HealthcarecoreCommunity-based clinical site network using CRIO's intuitive CTMS to standardize operations and embed quality by design.
- LightshipcoreSite network selected CRIO eSource and Site CTMS platform to support scalable trial execution across expanding site network.
- Society for Clinical Research Sites (SCRS)strategicLeading advocacy organization representing more than 11,000+ sites in 58 countries dedicated to unifying the voice of the global clinical research site community.
- Society for Clinical Data Management (SCDM)strategicNon-profit organization advancing Clinical Data Management through education, certification, and industry influence.
- Clinical Trials For AllstrategicNoncommercial initiative to increase global clinical trial participation by educating patients and caregivers about research opportunities.
Scale indicators16 records
Recent moves6 records
Expansion highlights6 records
Clinical Research IO competitors and assessment
Company assessmentDirect peers
- Florence Healthcare: Florence's eBinders (eISF/eRegulatory) and Trialbee platform target research sites and site networks with workflow, compliance, and document management solutions. Both compete for site-network technology budgets and recently acquired VersaTrial (Mike Wenger's prior venture, now CRIO's CIO).
- Advarra: Advarra offers eRegulatory (eReg/eISF), IRB, and site-centric clinical technology. It competes most directly with CRIO's eRegulatory and site workflow modules for site-network and academic medical center customers.
- Medrio: Medrio provides cloud-based EDC, ePRO, and eConsent for sponsors, CROs, and sites with a self-service SaaS model. It is comparable to CRIO in mid-market eClinical positioning and direct-to-site GTM motion.
- Medidata Solutions (Dassault Systèmes): Medidata is the dominant EDC and eClinical platform (Rave EDC, Rave eCOA, Rave Imaging) serving sponsors and CROs globally. It is simultaneously CRIO's flagship technology partner and its largest direct competitor in trial data capture; both target sponsors and CROs for clinical data workflows, though CRIO differentiates with site-centric eSource.
- Castor EDC: Castor offers a cloud-based eClinical platform combining EDC, eConsent, ePRO, and decentralized trial capabilities, targeting sponsors, CROs, and research sites. It is one of the most directly comparable standalone eClinical platforms to CRIO in terms of mid-market SaaS positioning and site-friendly UX.
Broad incumbents
- Signant Health: Signant provides eCOA, eConsent, patient engagement, and clinical supplies management to sponsors and CROs across global trials. It overlaps with CRIO's eConsent offering and competes for sponsor budget on patient-facing trial technology.
- Oracle Clinical One: Oracle Clinical One (built on the former Phase Forward / InForm assets) is a broad EDC, RTSM, and clinical platform used by large pharma sponsors. It competes for the same enterprise sponsor eSource/EDC budget CRIO targets through Central eSource and Reviewer EDC.
- Veeva Vault CTMS: Veeva Vault CTMS competes with CRIO's Site CTMS at larger sponsors and CROs that standardize on Veeva. Vault CTMS is part of Veeva's broader clinical suite, while CRIO's CTMS is integrated within its eSource-first site workflow.
- Veeva Systems: Veeva's Vault CDB, Vault CTMS, and eTMF serve large pharma sponsors with a broader clinical-platform suite. It competes with CRIO at the sponsor/CRO enterprise layer with significantly more scale, cross-application integration, and existing sponsor contracts.
Emerging players
- Medable: Medable is a leading decentralized clinical trial (DCT) platform serving sponsors and CROs with eCOA, telehealth, and patient engagement. It overlaps with CRIO's DCT-provider customer segment and competes for sponsor DCT technology spend.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights6 records
Customer concentration
Clinical Research IO social profiles
Digital presenceClinical Research IO compliance and trust
Trust signalCompliance9 records
Clinical Research IO financial estimates
Financial estimateRevenue estimate
Valuation estimate
Clinical Research IO leadership team
Management profileNumber of profiles
Profiles16 records
Clinical Research IO funding detail
Funding detailFunding overview
Funding rounds7 records
Investors6 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Clinical Research IO M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Clinical Research IO
What does Clinical Research IO do?
Clinical Research IO (CRIO) is a health technology company that builds and sells a cloud-based eSource (electronic source data capture) platform for clinical trials. The platform enables research sites to capture clinical trial data directly at the point of patient interaction, with integrated modules for EDC, eConsent, CTMS, eRegulatory, and reporting. CRIO sells subscriptions to sponsors, CROs, site networks, independent sites, academic medical centers, and decentralized clinical trial providers.
Is Clinical Research IO a public or private company?
Clinical Research IO is a private company. It is classified as private equity controlled and is currently operating.
When was Clinical Research IO founded?
Clinical Research IO was founded in 2015. It employs 101 to 250 people.
Where is Clinical Research IO based?
Clinical Research IO is headquartered in Boston, United States, in the North America region.
How does Clinical Research IO make money?
One revenue line is on record: saaS Subscription Platform.
Who are Clinical Research IO's main competitors?
Direct peers on record are Florence Healthcare, Advarra, Medrio, Medidata Solutions (Dassault Systèmes) and Castor EDC. Broad incumbents are Signant Health, Oracle Clinical One, Veeva Vault CTMS and Veeva Systems. Medable is listed as an emerging player.
Does Clinical Research IO have an API?
Yes. CRIO offers an open API enabling integrations with EDC solutions beyond existing partners. The platform also provides direct data access through Google BigQuery replica database with approximately 15 minutes latency, allowing clients to use their own business intelligence tools to query data. Developer documentation is at Not specified.
What industry is Clinical Research IO in?
Clinical Research IO's product category is Clinical Trial eSource Software. Its primary akta.pro industry code is HLAGAAAI, Patient Recruitment, Site Feasibility & Trial Enablement CROs. Its NAICS code is 541511 and its SIC code is 7372.