Clinical Research IO

What Clinical Research IO does

CRIO, Inc. (doing business as Clinical Research IO or CRIO) is a Boston-based health-technology company that operates a cloud-native eClinical platform anchored by an electronic source data capture (eSource) system for clinical trials. Founded in 2015 by Raymond Nomizu and Phuc Truong—both former site operators—the platform captures clinical-trial data directly at the point of patient interaction through configurable templates, protocol-driven edit checks, and integrated modules spanning electronic data capture (Reviewer EDC), eConsent, Site CTMS, eRegulatory, and reporting. A distinctive dual-database architecture separates PHI-enriched site instances from sponsor-side anonymized study databases, and a direct BigQuery replica exposes data to clients' business-intelligence tools with roughly 15-minute latency. The platform supports six languages across deployments in more than 30 countries.

CRIO serves four primary buyer segments: pharmaceutical and biotech sponsors, contract research organizations (CROs), independent and network clinical-research sites, and academic medical centers and decentralized-trial providers. Since 2025 the company has also sold Central eSource directly to sponsors and CROs, allowing enterprise buyers to deploy a central source template across participating sites while preserving local configuration. Pricing is quote-based, structured as annual subscriptions, with sponsors funding Central eSource deployments and sites gaining opt-in access without incremental charges.

The company sells primarily through direct enterprise field sales to sponsors, CROs, and site networks, supplemented by self-serve onboarding for individual sites via geographic portals and a 30+-partner channel ecosystem that includes Medidata (Dassault Systèmes) as a flagship technology partner, recruitment vendors, payment and patient-concierge providers, and implementation consultancies. The Riverside Company made a significant private-equity investment in May 2024 to accelerate international expansion, product development, and customer support. CRIO holds HIPAA, GDPR, 21 CFR Part 11, EU Annex 11, SOC 2 Type II, ISO 27001, GCP, HITECH, and CCPA certifications.

Name

Clinical Research IO

Legal name

CRIO, Inc.

Website

https://clinicalresearch.io

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

101–250 employees

Short description

CRIO operates a cloud-based eClinical platform with eSource, EDC, eConsent, CTMS, and eRegulatory modules, selling to clinical research sites, sponsors, CROs, and academic centers across 30+ countries. Founded in 2015 in Boston, the company is private-equity-backed and serves 3,000+ research sites on 6,000+ protocols.

Ownership category

akta.pro rank

Product category

Clinical Trial eSource Software

NAICS

Custom Computer Programming Services (541511)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

Patient Recruitment, Site Feasibility & Trial Enablement CROs (HLAGAAAI)

Keywords

• Clinical trial software
• Electronic data capture
• ESource platform
• Clinical research technology
• EClinical solutions

Headquarters

HQ city

Boston

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Operations, Marketing or Sales, Infrastructure

Revenue model

1. SaaS Subscription Platform: CRIO operates as a SaaS platform providing eSource, EDC, CTMS, eRegulatory, and eConsent solutions on a subscription basis. The platform is sold to clinical research sites, sponsors, and CROs. Sites that are existing CRIO clients are not charged for Central eSource studies if they opt-in — sponsors pay for Central eSource.

Pricing tiers

Go-to-market motion3 records

Distribution channels3 records

Marketing channels9 records

Core offering

Clinical Research IO (CRIO) is a health technology company that builds and sells a cloud-based eSource (electronic source data capture) platform for clinical trials. The platform enables research sites to capture clinical trial data directly at the point of patient interaction, with integrated modules for EDC, eConsent, CTMS, eRegulatory, and reporting. CRIO sells subscriptions to sponsors, CROs, site networks, independent sites, academic medical centers, and decentralized clinical trial providers.

Product overview

CRIO offers a unified eClinical platform with eSource at its core, combining Central eSource® (for sponsors and CROs) and Site eSource (for sites) with integrated modules including Reviewer EDC, eConsent, Site CTMS, eRegulatory, and Reporting. The platform is built for sites and designed to streamline clinical trial operations by capturing quality data at the point of collection, driving protocol compliance, and reducing administrative burden across sponsors, CROs, and research sites.

Differentiator

Problem solved

Functional benefit

Products and services

• eSource Platform Foundational electronic source data capture platform enabling clinical trial sites to collect data directly at the point of patient interaction with protocol-driven edit checks and integrated workflows.
• Central eSource® Centralized eSource solution allowing sponsors and CROs to develop a central source template, publish it to sites for local configuration, and enable real-time data access and remote monitoring across all sites.
• Site eSource Site-based eSource platform for clinical trial sites, networks, and academic medical centers to capture source data in real time with configurable templates, automated protocol checks, and integrated workflows.
• Reviewer EDC Native electronic data capture (EDC) solution integrated with CRIO eSource, enabling real-time remote monitoring, data review, query management, PI signature collection, and automated data flow with built-in WHODrug and MedDRA coding dictionaries.
• eConsent Electronic informed consent module integrated with eSource workflow that automates ICF management, tracks consent versions, enables remote consenting with PIN verification, and eliminates missed re-consent deviations.
• Site CTMS Site clinical trial management system for patient recruitment, scheduling, financial management, and operational streamlining, integrated with CRIO eSource platform and including a Medical Records API for EHR-to-eSource data pipeline.
• eRegulatory Electronic regulatory binder solution that eliminates paper, enables electronic investigator site files (eISF), automates training document management, and provides digital delegation logs.
• Reporting Comprehensive reporting suite with standard reports, custom report creation tools, direct data access to BigQuery replica database with approximately 15 minutes latency, and integration with business intelligence tools like Looker.
• Publisher Centralized application for sponsors and CROs to create, version, and push study templates to sites globally, enabling rapid template distribution and study startup.

Quantifiable outcome

• 40% higher enrollment for CRIO-powered sites vs. non-CRIO sites
• +11 more outcomes

Named customers16 records

Segments6 records

Ideal customer profiles6 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration34 records

AI capability8 records

Feature10 records

Partnerships

34 partnerships are on record, tiered flagship, core, minor and strategic.

• Medidata (Dassault Systèmes)flagshipTechnology or Integration · 5 March 2026Strategic partnership integrating CRIO's eSource platform with the Medidata Platform, connecting over 2,500 research sites across approximately 30 countries. The integration automates transfer of clinical data from research sites directly into electronic data capture systems, achieving near 100% data accuracy and 90% faster data entry.
• Grove (Grace AI Agent)coreTechnology or IntegrationAI-powered patient-matching platform that identifies, prescreens, schedules, and enrolls participants. Grace is multi-lingual and scales instantly for sites.
• Accelerate Recruitment ServicescoreChannel Partner/ Reseller/ DistributorClinical trial patient recruitment specialist offering strategic planning, recruitment and retention programs, and TruView platform for real-time engagement and reporting.
• StudyKIKcoreChannel Partner/ Reseller/ DistributorGlobal patient recruitment and retention platform offering digital marketing campaigns, dedicated study websites, global call center, telemedicine, SMS texting, and patient data management.
• TriallycoreTechnology or IntegrationAI-powered trial tech platform connecting to sites' clinical data and augmenting staff abilities to recruit, find studies, and prove feasibility.
• BEKhealthcoreTechnology or IntegrationAI-powered patient-matching platform extracting structured and unstructured data from EMRs that captures three times more trial criteria for feasibility and patient identification.
• PatientACEcoreChannel Partner/ Reseller/ DistributorSite-centric patient recruitment enabling easy setup of Facebook and Instagram ad campaigns with real-time lead delivery and automated text follow-up, seamlessly integrated with CRIO.
• Patient Recruiting Agency (TPRA)minorChannel Partner/ Reseller/ DistributorGlobal patient recruitment services including online and traditional media production, strategy development, and campaign placement with RADIUS365 referral delivery system integrated into CRIO.
• Precision RecruitmentminorChannel Partner/ Reseller/ DistributorAI-powered patient pre-screening and qualification call center with scalability of outsourced service.
• Delve HealthminorChannel Partner/ Reseller/ DistributorPatient concierge services increasing patient satisfaction, streamlining patient flow, and decreasing clinician burnout for improved retention.
• ClinrolminorChannel Partner/ Reseller/ DistributorAI-powered patient referral matching, pre-screening, and global patient recruitment services.
• CSSi (Rockstar Solution)minorChannel Partner/ Reseller/ DistributorTurnkey recruitment with real referrals and local support delivering fast starts, high ROI, and full-service retention.
• OMNI CRSminorChannel Partner/ Reseller/ DistributorPatient recruitment organization specializing in targeted lead generation, campaign management, and screener development.
• PowerminorChannel Partner/ Reseller/ DistributorPlatform helping people find and access leading medical researchers to accelerate medical innovation.
• Todata (SiteGrades)coreTechnology or IntegrationClinical research site operational data analytics transforming complex data into proactive insight and confident decision making.
• e4 HealthcoreImplementation/ SI/ Consulting PartnerHealth IT experts delivering structured CRIO implementation, legacy data mapping, and validation support for seamless site transitions.
• CoreforacoreImplementation/ SI/ Consulting PartnereSource management service handling builds, payments, team training, and capacity support so sites can focus on patients.
• Dash SolutionscoreTechnology or IntegrationClinical trial payment solutions enabling meaningful payments to patients through cash cards with prepayments and 1099 year-end reporting.
• Clinical Research BillingminorChannel Partner/ Reseller/ DistributorRevenue cycle management ensuring sites get paid for all work performed.
• InatominorChannel Partner/ Reseller/ DistributorFree clinical trial marketplace allowing sites to showcase capabilities and get selected for global trials with top sponsors.
• Site SearchminorChannel Partner/ Reseller/ DistributorComprehensive data reports and datasets for performance assessment, expansion insights, and strategic partnerships.
• Clinical Science Research SolutionsminorImplementation/ SI/ Consulting PartnerCRIO-integrated site development, workforce training, and DEI education for launching clinical research sites in underserved areas.
• Elevate Clinical ResearchminorImplementation/ SI/ Consulting PartnerSite Management Organization providing EDC data entry, eRegulatory management, and patient recruitment services.
• Koncord Clinical Research Services (KCRS)minorImplementation/ SI/ Consulting PartnerExpert site management and tailored solutions ensuring efficient, high-quality clinical study execution.
• UniTriTeamminorImplementation/ SI/ Consulting PartnerExpert staff augmentation and CRIO tech solutions streamlining operations and boosting efficiency.
• Healthcare Business AssociatesminorChannel Partner/ Reseller/ DistributorStrategic support for healthcare practices and research sites with commitment to long-term success.
• Pluto HealthstrategicTechnology or IntegrationPartnership (2023) connecting care and research through innovative integration of healthcare data.
• mdgroupcoreChannel Partner/ Reseller/ DistributorDecentralized clinical solutions and vendor management provider enabling home health visits with CRIO for real-time source data access.
• Heart of AustraliacoreChannel Partner/ Reseller/ DistributorMobile clinical research site using CRIO for flexible trial delivery and document storage in remote areas.
• EMS HealthcarecoreChannel Partner/ Reseller/ DistributorCommunity-based clinical site network using CRIO's intuitive CTMS to standardize operations and embed quality by design.
• LightshipcoreChannel Partner/ Reseller/ DistributorSite network selected CRIO eSource and Site CTMS platform to support scalable trial execution across expanding site network.
• Society for Clinical Research Sites (SCRS)strategicStrategic or Co-development PartnerLeading advocacy organization representing more than 11,000+ sites in 58 countries dedicated to unifying the voice of the global clinical research site community.
• Society for Clinical Data Management (SCDM)strategicStrategic or Co-development PartnerNon-profit organization advancing Clinical Data Management through education, certification, and industry influence.
• Clinical Trials For AllstrategicStrategic or Co-development PartnerNoncommercial initiative to increase global clinical trial participation by educating patients and caregivers about research opportunities.

Scale indicators16 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Florence Healthcare: Florence's eBinders (eISF/eRegulatory) and Trialbee platform target research sites and site networks with workflow, compliance, and document management solutions. Both compete for site-network technology budgets and recently acquired VersaTrial (Mike Wenger's prior venture, now CRIO's CIO).
• Advarra: Advarra offers eRegulatory (eReg/eISF), IRB, and site-centric clinical technology. It competes most directly with CRIO's eRegulatory and site workflow modules for site-network and academic medical center customers.
• Medrio: Medrio provides cloud-based EDC, ePRO, and eConsent for sponsors, CROs, and sites with a self-service SaaS model. It is comparable to CRIO in mid-market eClinical positioning and direct-to-site GTM motion.
• Medidata Solutions (Dassault Systèmes): Medidata is the dominant EDC and eClinical platform (Rave EDC, Rave eCOA, Rave Imaging) serving sponsors and CROs globally. It is simultaneously CRIO's flagship technology partner and its largest direct competitor in trial data capture; both target sponsors and CROs for clinical data workflows, though CRIO differentiates with site-centric eSource.
• Castor EDC: Castor offers a cloud-based eClinical platform combining EDC, eConsent, ePRO, and decentralized trial capabilities, targeting sponsors, CROs, and research sites. It is one of the most directly comparable standalone eClinical platforms to CRIO in terms of mid-market SaaS positioning and site-friendly UX.

Broad incumbents

• Signant Health: Signant provides eCOA, eConsent, patient engagement, and clinical supplies management to sponsors and CROs across global trials. It overlaps with CRIO's eConsent offering and competes for sponsor budget on patient-facing trial technology.
• Oracle Clinical One: Oracle Clinical One (built on the former Phase Forward / InForm assets) is a broad EDC, RTSM, and clinical platform used by large pharma sponsors. It competes for the same enterprise sponsor eSource/EDC budget CRIO targets through Central eSource and Reviewer EDC.
• Veeva Vault CTMS: Veeva Vault CTMS competes with CRIO's Site CTMS at larger sponsors and CROs that standardize on Veeva. Vault CTMS is part of Veeva's broader clinical suite, while CRIO's CTMS is integrated within its eSource-first site workflow.
• Veeva Systems: Veeva's Vault CDB, Vault CTMS, and eTMF serve large pharma sponsors with a broader clinical-platform suite. It competes with CRIO at the sponsor/CRO enterprise layer with significantly more scale, cross-application integration, and existing sponsor contracts.

Emerging players

• Medable: Medable is a leading decentralized clinical trial (DCT) platform serving sponsors and CROs with eCOA, telehealth, and patient engagement. It overlaps with CRIO's DCT-provider customer segment and competes for sponsor DCT technology spend.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/channel/UCjFGTOGY9cqKjL73Zab5w7A
• LinkedInlinkedin.com/company/clinical-research-io
• Xx.com/TeamCRIO

Compliance9 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles16 records

Funding overview

Funding rounds7 records

Investors6 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Clinical Research IO